D3 Receptors
D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja where they are involved in the modulation of locomotion and have a possible role in cognition and emotion. The human D3 receptor gene has been localized to chromosome 3 (3q13.3).
- IUPHAR Receptor code: D3
- BJP Guide: D3
D3 Receptor Gene Data
| Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| Human | DRD3 | NM_033660 | P35462 |
| Mouse | Drd3 | NM_007877 | P30728 |
| Rat | Drd3 | NM_017140 | P19020 |
D3 Receptor Products
Featured Products |
|
Cat.No. |
Product Name / Activity |
| 1347 | Nafadotride |
| Highly potent, preferential D3 antagonist | |
| 1243 | (+)-PD 128907 hydrochloride |
| D3 agonist (D3 ≥ D2 > D4) | |
Agonists |
|
Cat.No. |
Product Name / Activity |
| 0706 | 7-Hydroxy-DPAT hydrobromide |
| Dopamine agonist (D3 ≥ D2 < > D4) | |
| 0719 | 7-Hydroxy-PIPAT maleate |
| D3 agonist (D3 > D2) | |
| 1243 | (+)-PD 128907 hydrochloride |
| D3 agonist (D3 ≥ D2 > D4) | |
| 3896 |
Rotigotine hydrochloride |
| Dopamine D2/D3 agonist | |
Antagonists |
|
Cat.No. |
Product Name / Activity |
| 1847 | Eticlopride hydrochloride |
| D3 antagonist (D3 > D2) | |
| 1109 | GR 103691 |
| Highly selective D3 antagonist | |
| 3940 |
GSK 789472 hydrochloride |
| D3 antagonist. Also D2 partial agonist | |
| 1347 | Nafadotride |
| Highly potent, preferential D3 antagonist | |
| 2635 | NGB 2904 |
| Potent and selective D3 antagonist | |
| 3355 | PNU 177864 hydrochloride |
| Highly selective D3 antagonist | |
| 1357 | U 99194 maleate |
| Potent, selective D3 antagonist | |
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