D2 Receptors
D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are located primarily in the caudate putamen, nucleus accumbens and olfactory tubercle where they are involved in the modulation of locomotion, reward, reinforcement and memory and learning. The human D2 receptor gene has been localized to chromosome 11 (11q22-23).
- IUPHAR Receptor code: D2
- BJP Guide: D2
D2 Receptor Gene Data
| Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| Human | DRD2 | NM_000795 | P14416 |
| Mouse | Drd2 | NM_010077 | P61168 |
| Rat | Drd2 | NM_012547 | P61169 |
D2 Receptor Products
Featured Products |
|
Cat.No. |
Product Name / Activity |
| 1003 | L-741,626 |
| High affinity D2 antagonist | |
Agonists |
|
Cat.No. |
Product Name / Activity |
| 2759 | B-HT 920 |
| D2 receptor agonist. Also α2 agonist and 5-HT3 antagonist | |
| 3940 |
GSK 789472 hydrochloride |
| D2 partial agonist; D3 antagonist | |
| 3896 |
Rotigotine hydrochloride |
| Dopamine D2/D3 agonist | |
Antagonists |
|
Cat.No. |
Product Name / Activity |
| 1003 | L-741,626 |
| High affinity D2 antagonist | |
| 2495 | Melperone hydrochloride |
| D2/5-HT2A receptor antagonist; neuroleptic | |
| 3287 | Prochlorperazine dimaleate |
| D2 receptor antagonist. Also 5-HT3 and nAChR antagonists | |
| 2865 | Risperidone |
| D2 antagonist. Also 5-HT2A antagonist | |
| 3085 | Ziprasidone hydrochloride |
| 5-HT2A/D2 antagonist; atypical antipsychotic | |
| 3996 |
Zotepine |
| 5-HT2A/D2 antagonist; atypical antipsychotic | |
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