Contact Us | Register | Login

Pharmacology All Targets 7-TM Receptors Ion Channels Nuclear Receptors Enzyme-Linked Receptors Transporters Enzymes Other Pharmacology Cellular Processes Angiogenesis Apoptosis Cell Cycle Cell Metabolism Cytoskeleton & Motor Proteins ECM & Adhesion Molecules Epigenetics Signal Transduction Stem Cells Signaling Pathways Product Type All Products New Products Small Molecules Peptides Controlled Substances Toxins Caged Compounds Fluorescent Probes Screening Libraries Ligand Sets Other Product Types Research Area Cancer Cardiovascular System Endocrinology Immunology Neuroscience Pain & Inflammation Respiratory System

Acetylcholine Nicotinic Receptors

Nicotinic receptors (nAChRs) are ligand-gated ion channels that modulate cell membrane potentials. Each receptor is composed of pentameric combinations of subunits (α1-10, β1-4, δ, ε and γ). Nicotinic receptors are generally divided into three functional classes: muscle subunits (α1, β1, δ, ε, γ), standard neuronal subunits (α1-6 and β2-4) that form in pairwise αβ combinations, and subunits (α7-9) that can form homomeric nAChRs. Neuronal nicotinic receptors are found in the central nervous system and in autonomic ganglia where they regulate processes such as transmitter release, cell excitability and neuronal integration. Nicotinic receptors located at the neuromuscular junctions of somatic muscles are responsible for muscular contraction.

Acetylcholine Nicotinic Receptor Target Files

Related Categories

© Copyright 2013 Tocris Bioscience. All Rights Reserved | Privacy and Cookie Policy | Site map