GABA Transporters

More Information »GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters have been identified and localized to neurons and glia.

GABA Products

Inhibitors
Cat.No.	Product Name / Activity
0206	β-Alanine
	GABA uptake inhibitor (GAT-2 and -3). Also glycine receptor agonist
1296	CI 966 hydrochloride
	Selective inhibitor of GAT-1
0234	Guvacine hydrochloride
	Specific GABA uptake inhibitor
0236	(±)-Nipecotic acid
	GABA uptake inhibitor
2747	NNC 05-2090 hydrochloride
	GABA uptake inhibitor; moderately BGT-1 selective
1779	NNC 711
	Selective inhibitor of GAT-1
0768	Riluzole hydrochloride
	GABA uptake inhibitor. Also glutamate release inhibitor
1081	SKF 89976A hydrochloride
	Potent GABA uptake inhibitor. Penetrates blood brain barrier
1561	(S)-SNAP 5114
	GABA uptake inhibitor
0181	TACA
	GABA uptake inhibitor. Also GABA_A agonist and substrate for GABA-T
4256	Tiagabine hydrochloride
	GABA uptake inhibitor; anticonvulsant

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GABA Review

Written by Ian Martin, Norman Bowery & Susan Dunn. Request a copy or view PDF today.

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.