Signal Transduction
Stem Cells
Signaling Pathways
Product Type
All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
Fluorescent Probes
Screening Libraries
Ligand Sets
Other Product Types
Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
GABAB Receptors
More Information »GABAB receptors are metabotropic G-protein-coupled receptors responsible for mediating the inhibitory effects of GABA alongside ionotropic GABAA and GABAC receptors. They exist as heterodimers of GABAB1 and GABAB2 subunits, with both required for function.
GABAB Receptor Products
Agonists |
|
Cat.No. |
Product Name / Activity |
| 3618 | Acamprosate calcium |
| GABA agonist and glutamatergic modulator | |
| 0796 | (R)-Baclofen |
| Selective GABAB agonist. Active enantiomer of (RS)-Baclofen (Cat. No. 0417) | |
| 0417 | (RS)-Baclofen |
| Selective GABAB agonist | |
| 0344 | GABA |
| Endogenous agonist | |
| 3400 | RuBi-GABA |
| Caged GABA; excitable by visible wavelength | |
| 4709 |
RuBi GABA trimethylphosphine
|
| Caged GABA; inhibits neural activity | |
| 0379 | SKF 97541 |
| Extremely potent GABAB agonist | |
Antagonists |
|
Cat.No. |
Product Name / Activity |
| 1245 | CGP 35348 |
| Brain penetrant, selective GABAB antagonist | |
| 3219 | CGP 36216 hydrochloride |
| GABAB antagonist; displays activity at presynaptic receptors | |
| 1247 | CGP 46381 |
| Brain penetrant, selective GABAB antagonist | |
| 1246 | CGP 52432 |
| Potent, selective GABAB antagonist | |
| 1088 | CGP 54626 hydrochloride |
| Potent, selective GABAB antagonist | |
| 1248 | CGP 55845 hydrochloride |
| Potent, selective GABAB antagonist | |
| 0245 | 2-Hydroxysaclofen |
| Selective GABAB antagonist, more potent than saclofen (Cat. No. 0246) | |
| 0178 | Phaclofen |
| Weak, selective GABAB antagonist | |
| 0246 | Saclofen |
| Selective GABAB antagonist | |
| 0984 | SCH 50911 |
| Selective, competitive, orally active GABAB antagonist | |
Modulators |
|
Cat.No. |
Product Name / Activity |
| 3313 | rac BHFF |
| Potent, selective GABAB positive allosteric modulator | |
| 1514 | CGP 13501 |
| Positive modulator at GABAB receptors | |
| 1513 | CGP 7930 |
| Positive modulator at GABAB receptors | |
| 2001 | GS 39783 |
| Positive modulator at GABAB receptors | |
Other |
|
Cat.No. |
Product Name / Activity |
| 1814 | N-ArachidonylGABA |
| Inhibits pain in vivo | |
| 0806 | Gabapentin |
| Anticonvulsant. Increases brain GABA | |
| 0538 | trans-4-Hydroxycrotonic acid |
| GHB receptor ligand | |
| 0386 | 3-Methyl-GABA |
| Activator of GABA amino-transferase | |
| 1811 | Modafinil |
| Psychostimulant | |
| 0780 | NCS-382 |
| Antagonist of γ-hydroxybutyric acid | |
| 4579 | Pentobarbital sodium salt |
| Enhances GABAergic activity | |
| 2687 | Pentylenetetrazole |
| CNS stimulant | |
| 4578 | Phenobarbital sodium salt |
| Enhances GABAergic activity | |
| 2815 | Valproic acid, sodium salt |
| Increases GABA levels; anticonvulsant | |
| 0808 | Vigabatrin |
| GABA-T inhibitor | |
| 2625 | Zonisamide |
| Anticonvulsant, modulates GABA neurotransmission | |
Related Categories
Quick Order
Find multiple products by catalog number
Pain Research Guide
Reserve your free copy
Highlights over 280 products for Pain research. Reserve copy
7-TM Receptor Signaling
Written by T. Kenakin et al
'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy
Therapeutic Strategies in Schizophrenia
Written by J. Lieberman
'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.
Tocris Events
Win a Kindle
British Cardiovascular Society Annual Conference 2013
June 3 - 5, 2013
London, UK
Booth Number: C54