NMDA Receptors

More Information »NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.

NMDA Receptor Products

Agonists
Cat.No.	Product Name / Activity
0186	cis-ACPD
	Potent NMDA agonist. Also group II mGluR agonist
0213	D-Aspartic acid
	NMDA agonist
0214	L-Aspartic acid
	NMDA agonist
0216	L-Cysteinesulfinic acid
	NMDA and mGlu agonist
3406	GLYX 13
	NMDA receptor partial agonist; acts at the glycine site
0281	(R)-(+)-HA-966
	NMDA partial agonist/antagonist, acts at glycine site
0197	Homoquinolinic acid
	Selective, potent NMDA agonist
0285	Ibotenic acid
	Non-selective NMDA agonist
2277	MNI-caged-D-aspartate
	Caged D-aspartate; NMDA agonist
0114	NMDA
	Selective NMDA agonist
0959	Spermidine trihydrochloride
	Agonist at polyamine site
0312	(RS)-(Tetrazol-5-yl)glycine
	Highly potent NMDA receptor agonist
Antagonists
Cat.No.	Product Name / Activity
0258	ACBC
	NMDA antagonist, acts at glycine site
3693	DL-AP5 Sodium salt
	Sodium salt of DL-AP5 (Cat. No. 0105)
0106	D-AP5
	Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105)
0105	DL-AP5
	Potent, selective NMDA antagonist
0107	L-AP5
	Potent, selective NMDA antagonist. Less active form of DL-AP5 (Cat. No. 0105)
0164	D-AP7
	Specific NMDA antagonist. More active form of DL-AP7 (Cat. No. 0104)
0104	DL-AP7
	Specific NMDA antagonist
0389	Arcaine sulfate
	Competitive NMDA antagonist
0322	(R)-4-Carboxyphenylglycine
	Moderately potent NMDA antagonist
1469	CGP 37849
	Potent selective NMDA antagonist
1409	CGP 39551
	Potent, selective and competitive NMDA antagonist
1493	CGP 78608 hydrochloride
	Potent, selective glycine-site NMDA antagonist
1241	CGS 19755
	Potent, competitive NMDA antagonist
3697	7-Chlorokynurenic acid sodium salt
	Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
0237	7-Chlorokynurenic acid
	NMDA antagonist, acts glycine site
0817	(2R,3S)-Chlorpheg
	Weak NMDA antagonist
0190	CNQX
	NMDA antagonist, acts glycine site. Also AMPA/kainate antagonist
2456	Co 101244 hydrochloride
	Highly selective NR2B antagonist
3125	Conantokin-R
	Potent non-competitive NMDA receptor antagonist
3122	Conantokin-T
	Non-competitive NMDA receptor antagonist
0247	(R)-CPP
	Potent NMDA antagonist. More active enantiomer of (RS)-CPP (Cat. No. 0173)
0173	(RS)-CPP
	Potent NMDA antagonist
1265	D-CPP-ene
	Potent, competitive NMDA antagonist
3071	Dextromethorphan hydrobromide
	NMDA receptor antagonist
0286	5,7-Dichlorokynurenic acid
	Potent NMDA antagonist, acts glycine site
3698	5,7-Dichlorokynurenic acid sodium salt
	Sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286). Potent NMDA antagonist, acts at glycine site
0360	(±)-1-(1,2-Diphenylethyl)piperidine maleate
	NMDA antagonist, acts ion channel site
4491	DQP 1105
	Selective NR2C/NR2D receptor antagonist
2195	Eliprodil
	Non-competitive NR2B-selective NMDA antagonist
0869	Felbamate
	NMDA antagonist, acts glycine site
2867	Flupirtine maleate
	Indirect NMDA receptor antagonist
2348	Gavestinel
	Potent and selective glycine site antagonist. Orally available and active in vivo
0282	(S)-(-)-HA-966
	NMDA antagonist/partial agonist
2861	HU 211
	NMDA receptor antagonist. Also NF-κB inhibitor
0290	N-(4-Hydroxyphenylacetyl)spermine
	Wasp toxin analog
0545	Ifenprodil hemitartrate
	Non-competitive NMDA antagonist. Also σ ligand
2892	threo Ifenprodil hemitartrate
	NR2B-selective NMDA antagonist. Also σ agonist
3131	Ketamine hydrochloride
	Non-competitive NMDA receptor antagonist
4379	(S)-(+)-Ketamine hydrochloride
	NMDA receptor antagonist; enantiomer of ketamine hydrochloride (Cat. No. 3131)
0742	L-689,560
	Very potent NMDA antagonist
0705	L-701,252
	NMDA antagonist, acts glycine site
0907	L-701,324
	NMDA antagonist, acts at glycine site
0840	Loperamide hydrochloride
	NMDA antagonist, reduces Ca²⁺ flux
1521	LY 233053
	Competitive NMDA receptor antagonist
1019	LY 235959
	Competitive NMDA antagonist
0773	Memantine hydrochloride
	NMDA antagonist; acts at ion channel site
0955	(-)-MK 801 maleate
	NMDA antagonist, less active enantiomer
0924	(+)-MK 801 maleate
	Non-competitive NMDA antagonist, acts at ion channel site
1970	Norketamine hydrochloride
	Potent, non-competitive NMDA antagonist
4230	NPEC-caged-D-AP5
	Caged D-AP5 (Cat.No. 0106); NMDA antagonist
3277	Pentamidine isethionate
	Antimicrobial that antagonizes NMDA receptors
2557	Phencyclidine hydrochloride
	Non-competitive NMDA receptor antagonist
2273	PMPA (NMDA antagonist)
	Competitive NMDA antagonist
2530	PPDA
	Subtype-selective NR2C/NR2D antagonist
2274	PPPA
	Competitive NR2A antagonist
1622	Remacemide hydrochloride
	NMDA antagonist; blocks ion channel and allosteric modulatory site
2005	Ro 04-5595 hydrochloride
	Selective NR2B antagonist
1594	Ro 25-6981 maleate
	Subtype-selective NR2B antagonist
3254	Ro 61-8048
	NMDA antagonist; increases kynurenic acid levels
3343	Ro 8-4304 hydrochloride
	Selective NR2B antagonist
1251	SDZ 220-040
	Potent, competitive NMDA antagonist
1250	SDZ 220-581
	Competitive NMDA antagonist
0635	Synthalin sulfate
	Non-competitive NMDA antagonist
4154	TCN 201
	Selective NR1/NR2A receptor antagonist
4163	TCN 213
	NMDA antagonist; selective for NR2A over NR2B
4072	TCN 237 dihydrochloride
	Highly potent and selective NR2B antagonist
2782	TCS 46b
	Orally active, subtype-selective NR1A/NR2B antagonist
Ligand Sets
Cat.No.	Product Name / Activity
1825	Mixed NMDA Receptor Tocriset™
	Selection of 5 mixed NMDA receptor ligands (Cat. Nos. 0114, 0312, 0106, 0924 and 1241)
1823	NMDA Receptor - Glycine Site Tocriset™
	Selection of 5 NMDA receptor (glycine site) ligands (Cat. Nos. 0219, 0281, 0742, 1493 and 0237)
Other
Cat.No.	Product Name / Activity
1238	CCMQ
	Used to characterize NR2B-containing NMDA receptors
4105	CIQ
	Potentiator of NMDA receptors containing NR2C/NR2D
0219	Glycine
	Endogenous potentiator, co-transmitter
1636	IEM 1460
	Open-channel blocker of NMDA currents. Also blocks AMPA currents
2224	MNI-caged-NMDA
	Caged NMDA
2213	N20C hydrochloride
	Non-competitive NMDA receptor open-channel blocker
2851	Nefiracetam
	Cognitive enhancer; potentiates NMDA currents
0225	Quinolinic acid
	Endogenous NMDA agonist and transmitter candidate
0226	D-Serine
	Potentiator, acts glycine site
0958	Spermine tetrahydrochloride
	Modulator at polyamine site

Related Categories

AMPA Receptors Kainate Receptors

Glutamate (Metabotropic) Receptors Glutamate (EAAT) Transporters

Quick Order

Find multiple products by catalog number

Pain Research Guide

Reserve your free copy

Highlights over 280 products for Pain research. Reserve copy

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.

Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.

Neurobiology of Parkinson's Disease

Written by A. Schapira

'Neurobiology and Therapeutics of Parkinson's Disease' highlights the neurobiology of Parkinson's disease and summarizes current and novel therapeutic interventions.