R&D Systems Inc. Tocris Bioscience Boston Biochem

Calcium-Activated Potassium (KCa) Channels

More Information »Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).

Calcium-Activated Potassium (KCa) Channel Products

Modulators
Cat.No.
Product Name / Activity
4949 MaxiPost
Positive channel modulator; exerts subtype-specific effects
Activators
Cat.No.
Product Name / Activity
2665 BMS 191011
Potent BKCa (KCa1.1) channel opener
2953 CyPPA
Activator of KCa2.2 and KCa2.3 channels
1422 DCEBIO
More potent analog of 1-EBIO (Cat. No. 1041). Activates hKCa3.1/Cl- conductance
1041 1-EBIO
Activator of epithelial KCa channels
4311 GW 542573X
Selective activator of KCa2.1 channels
4788 NS 11021
Activator of BKCa (KCa1.1) channels
3804 NS 1619
Activator of BKCa (KCa1.1) channels
3895 NS 309
Positive modulator of KCa2 and KCa3.1 channels
3670 SKA 31
Activator of KCa3.1 and KCa2 channels
Blockers
Cat.No.
Product Name / Activity
1652 Apamin
KCa2 channel blocker (small conductance)
1087 Charybdotoxin
KCa channel blocker (big conductance)
1086 Iberiotoxin
KCa channel blocker (big conductance)
3564 Kaliotoxin
KCa and KV blocker
4864 NS 6180
Potent KCa3.1 channel blocker
2006 Paxilline
Potent blocker of BKCa (KCa1.1) channels
4617 Penitrem A
Potent and selective BKCa (KCa1.1) channel blocker
2946 TRAM 34
Highly selective KCa3.1 channel blocker
1310 UCL 1684
Highly potent blocker of KCa2
2661 UCL 2077
Slow afterhyperpolarization (sAHP) channel blocker
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