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Ubiquitin Ligases

More Information »Ubiquitin ligases (EC 6.3.2.19) attach ubiquitin molecules onto lysine residues of proteins in order to target the protein for a specific cellular process, such as proteasomal degradation or an alteration in subcellular localization.

Ubiquitin Ligases Products

Inhibitors
Cat.No.	Product Name / Activity
3503	HLI 373
	Hdm2 inhibitor; activates p53-dependent transcription
2936	NSC 66811
	MDM2 antagonist. Disrupts MDM2-p53 interaction
3984	Nutlin-3
	MDM2 antagonist; inhibits MDM2-p53 interaction
2978	PYR 41
	Ubiquitin-activating enzyme (E1) inhibitor
2443	RITA
	MDM2-p53 interaction inhibitor
4817	SKPin C1
	Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
4375	SMER 3
	Specific inhibitor of E3 ubiquitin ligase
4506	TAME hydrochloride
	Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination
Other
Cat.No.	Product Name / Activity
3365	Tenovin-1
	Protects against MDM2-mediated p53 degradation

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