Stem Cell Signaling

More Information »Various stem cell signaling pathways influence stem cell generation, self-renewal and differentiation. In vivo, the microenvironment responsible for maintaining stem cells in pluripotent form and enabling their self-renewal is called the stem-cell niche.

Stem Cell Signaling Products

Inhibitors
Cat.No.	Product Name / Activity
4855	WIKI4
	Tankyrase inhibitor; inhibits Wnt signaling
Other
Cat.No.	Product Name / Activity
3194	BIO
	Potent, selective GSK-3 inhibitor
3874	BIO-acetoxime
	Selective GSK-3α/β inhibitor; inhibits CD8+ T cell effector differentiation
4529	Ciliobrevin A
	Hedgehog pathway antagonist; inhibits ciliogenesis
1623	Cyclopamine
	Inhibitor of Hedgehog (Hh) signaling
4027	16,16-Dimethyl Prostaglandin E2
	Synthetic prostaglandin E₂ (Cat. No. 2296) derivative; regulates HSC development
1769	Flurbiprofen
	Cyclooxygenase inhibitor; regulates prostate stem cell antigen
3889	GANT 58
	GLI1 antagonist; inhibits Hh signaling
3191	GANT 61
	GLI antagonist; inhibits Hh signaling
1368	Geldanamycin
	Selective Hsp90 inhibitor
4474	20(S)-Hydroxycholesterol
	Allosteric activator of Hedgehog signaling; induces Smo accumulation
3533	IWP 2
	Inhibitor of Wnt processing and secretion; suppresses self-renewal in R1 ESCs
3532	endo-IWR 1
	Axin stabilizer; promotes β-catenin phosphorylation
3341	JK 184
	Downstream Hh signaling pathway inhibitor; inhibits alcohol dehydrogenase 7
1398	Kenpaullone
	GSK-3 inhibitor; can be used to generate iPSCs
4079	Niclosamide
	STAT3 and mTORC1 signaling inhibitor; antineoplastic against AML stem cells
1267	Pifithrin-α hydrobromide
	p53 inhibitor. Also aryl hydrocarbon receptor agonist
2296	Prostaglandin E₂
	Major endogenous prostanoid
3324	QS 11
	ARFGAP1 inhibitor; modulates Wnt signaling pathway
3667	SR 3677 dihydrochloride
	Potent, selective Rho-kinase (ROCK) inhibitor
3748	XAV 939
	Tankyrase inhibitor; promotes cardiomyogenesis