Stem Cell Dedifferentiation

More Information »Cellular dedifferentiation is the regression of a cell from a more specialized state back to a simpler state that confers pluripotency, giving rise to cells reminiscent of stem cells. This process is more commonly studied in plants and also in more basal life forms.

Stem Cell Dedifferentiation Products


Cat.No.	Product Name / Activity
4055	L-Ascorbic acid
	Enhances the generation of iPSCs; increases reprogramming efficiency
3842	5-Azacytidine
	DNA methyltransferase inhibitor. Improves reprogramming efficiency
1544	(±)-Bay K 8644
	Ca²⁺-channel activator (L-type)
3364	BIX 01294
	G9a-like protein and G9a HMTase inhibitor; potentiates induction of iPSCs
4423	CHIR 99021
	Highly selective GSK-3 inhibitor; enables reprogramming of mouse embryonic fibroblasts into iPS cells
4713	IQ 1
	Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation
1398	Kenpaullone
	Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3
1267	Pifithrin-α hydrobromide
	p53 inhibitor. Also aryl hydrocarbon receptor agonist
2653	Pifithrin-μ
	Inhibitor of p53-mitochondrial binding
3742	RepSox
	Selective TGF-βRI inhibitor; enhances reprogramming efficiency
3295	RG 108
	Non-nucleoside DNA methyltransferase inhibitor; enhances efficiency of iPSC generation
3845	Thiazovivin
	Improves the efficiency of fibroblast reprogramming and induction of iPSCs
3852	Tranylcypromine hydrochloride
	Irreversible inhibitor of LSD1; enables reprogramming of mouse embryonic fibroblasts into iPS cells
1406	Trichostatin A
	Histone deacetylase inhibitor; induces accelerated dedifferentiation of primordial germ cells
2815	Valproic acid, sodium salt
	Histone deacetylase inhibitor; enables induction of pluripotent stem cells from somatic cells