Integrin Receptors

More Information »Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of α and β subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca²⁺ or Mg²⁺ ion, which is essential for ligand binding.

Integrin Receptor Products

Antagonists
Cat.No.	Product Name / Activity
4744	P11
	Potent antagonist of α_vβ₃-vitronectin interaction; antiangiogenic
Inhibitors
Cat.No.	Product Name / Activity
2524	A 205804
	Selective inhibitor of E-selectin and ICAM-1 expression
4228	A 286982
	Potent inhibitor of the LFA-1/ICAM-1 interaction
3910	BIO 1211
	Selective α₄β₁ (VLA-4) inhibitor
3202	Echistatin, α1 isoform
	α_Vβ₃ and glycoprotein IIb/IIIa (integrin α_IIbβ₃) inhibitor
4725	Eptifibatide
	Glycoprotein IIa/IIIb inhibitor; inhibits platelet aggregation
1263	GR 144053 trihydrochloride
	Glycoprotein IIb/IIIa (integrin α_IIbβ₃) receptor antagonist. Antithrombotic
2877	MNS
	Glycoprotein IIb/IIIa (α_IIbβ₃) inhibitor. Also inhibits Src and Syk
3498	RGDS peptide
	Integrin binding sequence; inhibits integrin receptor function
4227	RWJ 50271
	Inhibitor of LFA-1/ICAM mediated cell adhesion
3900	TCS 2314
	α₄β₁ (VLA-4) antagonist
Other
Cat.No.	Product Name / Activity
4577	LDV FITC
	Fluorescent ligand for α₄β₁ (VLA-4)
4664	Obtustatin
	Potent and selective α₁β₁ inhibitor