Integrin Receptors

More Information »Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of α and β subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Integrin Receptor Products

Product Name / Activity
4776 BIRT 377
Potent negative allosteric modulator of LFA-1
Product Name / Activity
2524 A 205804
Selective inhibitor of E-selectin and ICAM-1 expression
4228 A 286982
Potent inhibitor of the LFA-1/ICAM-1 interaction
3910 BIO 1211
Selective α4β1 (VLA-4) inhibitor
5051 BIO 5192
Highly potent and selective inhibitor of integrin α4β1
4724 BTT 3033
Selective inhibitor of integrin α2β1
3202 Echistatin, α1 isoform
αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
4725 Eptifibatide
Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation
1263 GR 144053 trihydrochloride
Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
2877 MNS
Glycoprotein IIb/IIIa (αIIbβ3) inhibitor. Also inhibits Src and Syk
4664 Obtustatin
Potent and selective α1β1 inhibitor
4744 P11
Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
3498 RGDS peptide
Integrin binding sequence; inhibits integrin receptor function
4527 TC-I 15
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
3900 TCS 2314
α4β1 (VLA-4) antagonist
Product Name / Activity
4921 Leukadherin 1
Allosteric activator of CD11b/CD18
Product Name / Activity
Fluorescent ligand for α4β1 (VLA-4)
4227 RWJ 50271
Inhibitor of LFA-1/ICAM mediated cell adhesion
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