MAPK Signaling

The mitogen-activated protein kinase (MAPK) family is a group of serine/threonine kinases that mediate intracellular signaling. The activation of MAPK involves a cascade consisting of MAPK kinase (also known as MAPKKK or MEKK) that activates MAPK/ERK (also known as MAPKK or MEK). This stimulates a phosphorylation-dependent increase in the activity of MAPK.

MAPK Signaling Target Files

AP-1 MAPK

MEK Raf Kinase

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

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Upon activation, MAPK can phosphorylate a variety of intracellular targets including transcription factors, transcriptional adaptor proteins, membrane and cytoplasmic substrates, and other protein kinases. Three major groups of MAPK cascades have been determined: ERK1/ERK2, JNK/SAPK and p38 MAPK.

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Cancer Research Guide

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Kinases Product Listing

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Kinase Inhibitor Toolbox

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New Therapies and Challenges in Asthma

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MAPK Pathway

The MAPK family kinases respond to extracellular stimuli such as heat and stress to mediate intracellular signals. View pathway or download PDF today.