R&D Systems Inc. Tocris Bioscience Boston Biochem

NF-κB & IκB

More Information »NF-κB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in the cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immunological response to infections.

NF-κB & IκB Products

Inhibitors
Cat.No.
Product Name / Activity
4547 ACHP
Selective IKKα and IKKβ inhibitor; blocks NF-κB-DNA binding
4857 Amlexanox
Inhibitor of TBK1 and IKKε; antiallergic agent
4626 Andrographolide
Inhibits NFκB; blocks androgen receptor (AR) expression
1777 Arctigenin
Inhibitor of IκBα phosphorylation. Also inhibits MEK1
1743 Bay 11-7085
Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
1744 Bay 11-7821
Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
2743 Caffeic acid phenethyl ester
Specific inhibitor of NF-κB activation
2509 Cardamonin
Inhibitor of NF-κB activation; anti-inflammatory
3203 Celastrol
Inhibits TNF-α-induced NF-κB activation
4246 CID 2858522
Selectively inhibits PKC-induced NF-κB activation
2637 Gliotoxin
Immunosuppressant; inhibits NF-κB and cytokine production
4590 Honokiol
Blocks NF-κB activation. Displays anti-inflammatory and antioxidant properties
2861 HU 211
NF-κB inhibitor; decreases TNF-α, IL-6 and NO production. Also NMDA antagonist
1532 10Z-Hymenialdisine
Pan kinase inhibitor; blocks NF-κB activation
2539 IKK 16
Selective inhibitor of IKK
2611 IMD 0354
Inhibitor of IKKβ
2874 Luteolin
Blocks NF-κB activation
1748 MG 132
Inhibits NF-κB activation; proteasome and calpain inhibitor
4899 ML 120B dihydrochloride
Novel IKK2-selective inhibitor
4354 ML 130
Inhibits NOD1-induced NF-κB activation
4238 PF 184
Potent and selective IKKβ inhibitor
1554 Piceatannol
Inhibits TNF-induced NF-κB activation
1947 PR 39 (porcine)
IκBα inhibitor
3731 Pristimerin
Suppresses NF-κB activation
4569 PS 1145 dihydrochloride
Selective IKK inhibitor; orally active
4045 PSI
Prevents activation of NF-κB. Also inhibits the proteasome
0727 Pyrrolidinedithiocarbamate ammonium
Inhibits NF-κB, prevents increase in NOS mRNA
1778 Ro 106-9920
Inhibitor of NF-κB activation
3318 SC 514
IKKβ inhibitor; attenuates NF-κB-induced gene expression
4935 Sulfasalazine
Inhibitor of NF-κB activation; also inhibits SXC
4426 Tanshinone IIA
Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties
2559 TPCA-1
Potent, selective inhibitor of IKKβ
2816 Withaferin A
Inhibits NF-κB activation
Activators
Cat.No.
Product Name / Activity
3906 Betulinic acid
Activates NF-κB; antitumor and anti-HIV agent. Also TGR5 agonist
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