Apoptosis Inducers

Apoptosis inducers exhibit pro-apoptotic effects through a variety of mechanisms, including DNA cross-linking, inhibition of antiapoptotic proteins and activation of caspases. These inducers may target a specific cellular process in order to induce antitumor or antineoplastic effects.

Apoptosis Inducing Products


Cat.No.	Product Name / Activity
1229	Actinomycin D
	Antineoplastic antibiotic
4846	Apicidin
	Histone deacetylase inhibitor; induces apoptosis
2098	Apoptosis Activator 2
	Selectively induces tumor cell apoptosis
3367	AT 101
	Downregulates Bcl-2 and Mcl-1; pro-apoptotic
4810	BAM 7
	Selective Bax activator; induces Bax-mediated apoptosis
3681	Bendamustine hydrochloride
	Cytostatic agent; exhibits DNA alkylating and purine analog properties
3906	Betulinic acid
	Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
2489	C 75
	Induces apoptosis and exhibits anti-tumor activity
2626	Carboplatin
	DNA cross-linking antitumor agent
3868	CHM 1
	Potent antitumor agent; inducer of apoptosis
2251	Cisplatin
	DNA-alkylating antitumor agent
2841	Curcumin
	Antitumor, anti-inflammatory and antioxidant
4091	Cyclophosphamide
	Alkylating agent; chemotherapeutic
2137	2,3-DCPE hydrochloride
	Selectively induces cancer cell apoptosis
1770	Deguelin
	Anticancer and antiviral agent; chemopreventive and pro-apoptotic
2252	Doxorubicin hydrochloride
	Antitumor antibiotic agent; induces apoptosis
3495	Fludarabine
	Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression
3590	Gambogic acid
	Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins
3603	Kaempferol
	Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca²⁺ uniporter
1807	2-Methoxyestradiol
	Apoptotic and antiangiogenic agent
3258	Mitomycin C
	DNA cross-linking antitumor agent
3715	Narciclasine
	Antiproliferative agent; exhibits pro-apoptotic effects
3427	Oncrasin 1
	Proapoptotic; induces abnormal nuclear accumulation of PKCι
2623	Oxaliplatin
	DNA cross-linking antitumor agent
4396	Piperlongumine
	Induces apoptosis; increases p53 and ROS levels in cancer cells
4761	Plumbagin
	Induces apoptosis; anticancer
1621	Streptozocin
	DNA alkylator; antitumor and induces diabetes
2706	Temozolomide
	DNA-methylating antitumor agent
4038	TW 37
	Bcl-2 inhibitor; induces apoptosis

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Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

A summary of the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation. Request a copy or view PDF today.