Caspases

More Information »Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Caspase Products

Inhibitors
Cat.No.	Product Name / Activity
2172	AZ 10417808
	Selective non-peptide caspase-3 inhibitor
2166	Z-DEVD-FMK
	Cell-permeable, irreversible caspase-3 inhibitor
2168	Z-DQMD-FMK
	Caspase-3 inhibitor
2636	Ivachtin
	Potent caspase-3 inhibitor
2163	Z-VAD-FMK
	Cell-permeable, irreversible caspase inhibitor
2165	Z-VDVAD-FMK
	Irreversible caspase-2 inhibitor
2169	Z-VEID-FMK
	Irreversible caspase-6 inhibitor
2167	Z-WEHD-FMK
	Caspase-5 inhibitor
Substrates
Cat.No.	Product Name / Activity
1576	Ac-IEPD-AFC
	Fluorogenic granzyme B substrate
1575	Ac-LEHD-AFC
	Fluorogenic caspase substrate
Activators
Cat.No.	Product Name / Activity
2251	Cisplatin
	Potent pro-apoptotic anticancer agent; activates caspase-3
3590	Gambogic acid
	Apoptosis inducer. Activates caspases
2581	PAC 1
	Activator of procaspase-3; pro-apoptotic
1758	PETCM
	Activator of caspase-3
Other
Cat.No.	Product Name / Activity
2098	Apoptosis Activator 2
	Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

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