R&D Systems Inc. Tocris Bioscience Boston Biochem

Trk Receptors

More Information »Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCγ signaling pathways. Four members of the Trk family have been identified.

Trk Receptor Products

Agonists
Cat.No.
Product Name / Activity
2837 BDNF (human)
Activates TrkB and p75 receptors
3826 7,8-Dihydroxyflavone
TrkB agonist
4607 LM 22A4
Potent TrkB agonist
Antagonists
Cat.No.
Product Name / Activity
4781 ANA 12
TrkB receptor antagonist
5062 Cyclotraxin B
TrkB receptor antagonist
Inhibitors
Cat.No.
Product Name / Activity
2617 AG 879
TrkA inhibitor
4559 GNF 5837
Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC
2238 GW 441756
Potent, selective TrkA inhibitor
3395 Lestaurtinib
TrkA, JAK2 and FLT3 inhibitor
2272 Ro 08-2750
Inhibits NGF binding to p75NTR and TrkA
Other
Cat.No.
Product Name / Activity
2087 NTR 368
p75NTR fragment; induces apoptosis
3051 TLQP 21
VGF-derived peptide
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