R&D Systems Inc. Tocris Bioscience Boston Biochem

γ-Secretase

More Information »γ-secretase is a multi-subunit internal protease that cleaves within the transmembrane domain of its substrates. It is an integral membrane protein and minimally consists of four proteins; presenilin, nicastrin, APH-1 and PEN-2. γ-secretase is involved in the processing of Notch.

γ-Secretase Products

Inhibitors
Cat.No.
Product Name / Activity
4283 Begacestat
γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
2870 BMS 299897
Potent γ-secretase inhibitor
2654 Compound W
γ-secretase inhibitor
2634 DAPT
γ-secretase inhibitor
4489 DBZ
γ-secretase inhibitor; inhibits Notch pathway
4495 Flurizan
γ-secretase inhibitor; lowers Aβ42 levels in vitro
2677 JLK 6
Inhibitor of γ-secretase-mediated βAPP processing
2627 L-685,458
Potent and selective γ-secretase inhibitor
4000 MRK 560
γ-secretase inhibitor; attenuates amyloid plaque deposition
Related Categories

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

divider line

The Neurobiology of Alzheimer's Disease

Written by Alan Palmer

Alzheimer's Poster

'The Neurobiology of Alzheimer's Disease' summarizes structural and functional changes observed in the progression of AD.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

Tocris Events

ICE/ENDO 2014

ICE/ENDO 2014

June 21 - 23, 2014

Chicago, USA