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γ-Secretase
More Information »γ-secretase is a multi-subunit internal protease that cleaves within the transmembrane domain of its substrates. It is an integral membrane protein and minimally consists of four proteins; presenilin, nicastrin, APH-1 and PEN-2. γ-secretase is involved in the processing of Notch.
γ-Secretase Products
Inhibitors |
|
Cat.No. |
Product Name / Activity |
| 4283 | Begacestat |
| γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels | |
| 2870 | BMS 299897 |
| Potent γ-secretase inhibitor | |
| 2654 | Compound W |
| γ-secretase inhibitor | |
| 2634 | DAPT |
| γ-secretase inhibitor | |
| 4489 |
DBZ
|
| γ-secretease inhibitor; inhibits Notch pathway | |
| 4495 | Flurizan |
| γ-secretase inhibitor; lowers Aβ42 levels in vitro | |
| 2677 | JLK 6 |
| Inhibitor of γ-secretase-mediated βAPP processing | |
| 2627 | L-685,458 |
| Potent and selective γ-secretase inhibitor | |
| 4000 | MRK 560 |
| γ-secretase inhibitor; attenuates amyloid plaque deposition | |
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