γ-Secretase

More Information »γ-secretase is a multi-subunit internal protease that cleaves within the transmembrane domain of its substrates. It is an integral membrane protein and minimally consists of four proteins; presenilin, nicastrin, APH-1 and PEN-2. γ-secretase is involved in the processing of Notch.

γ-Secretase Products

Modulators
Cat.No.
Product Name / Activity
4898 TC-E 5006
γ-secretase modulator; reduces Aβ42 levels
Inhibitors
Cat.No.
Product Name / Activity
4283 Begacestat
γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
2870 BMS 299897
Potent γ-secretase inhibitor
2654 Compound W
γ-secretase inhibitor
2634 DAPT
γ-secretase inhibitor
4489 DBZ
γ-secretase inhibitor; inhibits Notch pathway
4495 Flurizan
γ-secretase inhibitor; lowers Aβ42 levels in vitro
2677 JLK 6
Inhibitor of γ-secretase-mediated βAPP processing
2627 L-685,458
Potent and selective γ-secretase inhibitor
4000 MRK 560
γ-secretase inhibitor; attenuates amyloid plaque deposition
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