Dihydrofolate Reductase

More Information »Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. DHFR has a key role in cell growth and proliferation.

Dihydrofolate Reductase Products

Product Name / Activity
2039 CI 898 trihydrochloride
Dihydrofolate reductase inhibitor
1230 Methotrexate
Dihydrofolate reductase inhibitor
3918 Pyrimethamine
Potent inhibitor of multi-drug and toxin extrusion (MATE) transporters; also inhibits DHFR

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