Dihydrofolate Reductase

More Information »Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. DHFR has a key role in cell growth and proliferation.

Dihydrofolate Reductase Products

Inhibitors
Cat.No.	Product Name / Activity
2039	CI 898 trihydrochloride
	Dihydrofolate reductase inhibitor
1230	Methotrexate
	Dihydrofolate reductase inhibitor
3918	Pyrimethamine
	Potent inhibitor of multi-drug and toxin extrusion (MATE) transporters; also inhibits DHFR