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Leukotriene and Related Receptors
More Information »Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.
Leukotriene and Related Receptor Products
Agonists |
|
Cat.No. |
Product Name / Activity |
| 2307 | Leukotriene B4 |
| BLT1/BLT2 receptor agonist and potent chemotactic factor | |
| 1796 | 5-Oxo-ETE |
| Oxoeicosanoid receptor agonist | |
Antagonists |
|
Cat.No. |
Product Name / Activity |
| 3138 | BAY-u 9773 |
| Dual CysLT1 and CysLT2 antagonist | |
| 2025 | Cinalukast |
| Potent, selective CysLT1 (LTD4) antagonist; orally active | |
| 2276 | FPL 55712 |
| Leukotriene receptor antagonist | |
| 2140 | LY 171883 |
| Selective, orally active LTD4 antagonist | |
| 2208 | LY 255283 |
| Selective, competitive BLT2 receptor antagonist | |
| 2338 | MK 571 |
| Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor | |
| 3026 | ONO 1078 |
| Selective CysLT1 antagonist | |
| 1804 | SR 2640 hydrochloride |
| Potent, selective LTD4 /LTE4 receptor antagonist | |
Inhibitors |
|
Cat.No. |
Product Name / Activity |
| 3541 | BAY-X 1005 |
| Orally active 5-lipoxygenase activating protein (FLAP) inhibitor | |
| 4742 |
Gue 1654
|
| Selective inhibitor of OXE-R Gβγ signaling | |
Other |
|
Cat.No. |
Product Name / Activity |
| 2756 | Arachidonic acid (in Tocrisolve™100) |
| Endogenous free fatty acid (in water-soluble emulsion) | |
| 2709 | Cilastatin sodium |
| Dipeptidase inhibitor; inhibits metabolism of LTD4 to LTE4 | |
| 1311 | MK 886 |
| Inhibitor of 5-lipoxygenase-activating protein (FLAP) | |
| 0607 | 17-ODYA |
| LTB-ω-Hydroxylase inhibitor | |
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