Cat. No. 1099
Chemical Name: [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Ac
Biological ActivityCell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules (Cat. Nos. 3742, 4423 and 4703). Also available as part of the PKA Tocriset™.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Awad et al (1983) Interactions of forskolin and adenylate cyclase. J.Biol.Chem. 258 2960. PMID: 6681815.
Seamon et al (1983) Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J.Med.Chem. 26 436. PMID: 6681845.
Laurenza et al (1989) Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? TiPS 10 442. PMID: 2692256.
Kim et al (2005) cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK. Neuroreport 16 1357. PMID: 16056139.
Hou et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. 341 651. PMID: 23868920.
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Keywords: Forskolin, supplier, Adenylyl, cyclases, activator, Inositol, cAMP, Signaling, Signalling, adenylate, stem, cells
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July 7 - 11, 2015
Rio de Janeiro, Brazil