R&D Systems Inc. Tocris Bioscience Boston Biochem

Forskolin

Cat. No. 1099

Forskolin C22H34O7 [66575-29-9]

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Chemical Name: [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

Biological Activity

Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules (Cat. Nos. 3742, 4423 and 4703). Also available as part of the PKA Tocriset™.

Technical Data

M.Wt:
410.51
Formula:
C22H34O7
Solubility:
Soluble to 10 mM in ethanol and to 25 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
66575-29-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Awad et al (1983) Interactions of forskolin and adenylate cyclase. J.Biol.Chem. 258 2960. PMID: 6681815.

Seamon et al (1983) Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J.Med.Chem. 26 436. PMID: 6681845.

Laurenza et al (1989) Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? TiPS 10 442. PMID: 2692256.

Kim et al (2005) cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK. Neuroreport 16 1357. PMID: 16056139.

Hou et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. 341 651. PMID: 23868920.

If you know of a relevant citation for this product please let us know.

Keywords: Forskolin, supplier, Adenylyl, cyclases, activator, Inositol, cAMP, Signaling, Signalling, adenylate, stem, cells

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