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Spermidine trihydrochloride

Cat. No. 0959

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Chemical Name: N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride

Biological Activity

Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [³H]-MK801.

Technical Data

M.Wt:

254.63

Formula:

C₇H₁₉N₃.3HCl

Solubility:

Soluble to 100 mM in water

Storage:

Desiccate at +4°C

CAS No:

334-50-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Williams et al (1989) Effects of polyamines on the binding of [³H]-MK801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site. Mol.Pharmacol. 36 375. PMID: 2554112.

Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163. PMID: 8358608.

Kishi et al (1998) Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats. Brain Res. 793 311. PMID: 9630697.

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Keywords: Spermidine trihydrochloride, supplier, Agonist, polyamine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic

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