New Products

Cat.No.

Product Name / Activity

Positive allosteric modulator of α7 nAChR

Selective IKKα and IKKβ inhibitor

Potent and selective K_V1.3 channel blocker

Selective SIRT2 inhibitor; brain penetrant

Potent and selective p38α inhibitor

Inhibitor of TBK1 and IKKε; antiallergic agent

TrkB receptor antagonist

ASIC3 channel blocker

Histone deacetylase inhibitor

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Selective Bax activator; induces Bax-mediated apoptosis

NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative

Dual IR/IGF1R inhibitor

Potent, selective CCR1 antagonist

Selective cathepsin B inhibitor

Calcium-activated chloride channel (CaCC) inhibitor

AT₁ receptor antagonist

Prodrug of candesartan (Cat. No. 4791), an AT₁ receptor antagonist

Prodrug of 5-Fluorouracil (Cat. No. 3257). Inhibits DNA synthesis

Oxytocin analog

Inhibitor of Wnt/β-catenin signaling

Potassium channel blocker; neuroprotective

Selectively inhibits PKC-induced NF-κB activation

Positive allosteric modulator of GluA2 receptors

NR2B-selective NMDA receptor antagonist

Potent JAK inhibitor

Selective S1P₁ agonist

Fluorescent cytochrome P450 substrate

Potent and selective S1P₄ agonist

Potent and selective S1P₄ agonist

Potent NPY Y₂ receptor antagonist

Selective inhibitor of PI 3-Kinase γ

γ-secretease inhibitor; inhibits Notch pathway

PMAT inhibitor

Enantiomer of DPN (Cat. No. 1494)

Potent 5-HT and NE reuptake inhibitor; also blocks dopamine reuptake

Activator of Ca²⁺-activated Cl^- channel transmembrane protein 16A (TMEM16A)

Inhibits TRPP3-mediated currents; also inhibits the Na⁺/H⁺ exchanger (NHE)

Selective 5-HT_2A antagonist

Highly potent and selective OX₂ antagonist; brain penetrant

Glycoprotein IIa/IIIb inhibitor; inhibits platelet aggregation

Selective serotonin reuptake inhibitor (SSRI)

Cyclin-dependent kinase inhibitor

PAR₂ peptide antagonist

Selective GPR30 antagonist

Stretch-activated calcium channel blocker; calcium-sensing receptor agonist

Lactate dehydrogenase inhibitor; impairs aerobic glycolysis

High affinity, selective ClC-2 blocker; inhibits slow-gating

High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic

Geranylgeranyltransferase I (GGTase I) inhibitor

Selective LPA₂ receptor non-lipid agonist

Selective A_2B antagonist

Potent, selective LRRK2 inhibitor; brain penetrant

TRPC1 and TRPC6 blocker; inhibits mechanosensitive ion channels

Selective inhibitor of OXE-R Gβγ signaling

LPA_1,3,5 antagonist

Potent and selective LPA₂ receptor antagonist

Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor

Dual irreversible inhibitor of ErbB2 and EGFR

Inhibits Hedgehog signaling

Pan kinase inhibitor; potently inhibits MEK-1

Histone demethylase inhibitor; cell permeable

Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation

Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo

Selective Na_V1.5 channel blocker

Selective OX₂ receptor antagonist

Potent, selective BET bromodomain inhibitor; cell permeable

HIF-1α inhibitor; down-regulates HIF-1α protein synthesis

Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

FP prostaglandin receptor agonist; also exhibits agonist activity at EP₁ and EP₃ receptors

Synthetic progesterone analog

Selective casein kinase 1δ inhibitor

Mood stabilizer; inhibits Na⁺/K⁺ ATPase pump activity

Selective 5-HT₇ ligand

Protein kinase C inhibitor; selective for β isozymes

FFA1 (GPR40) agonist. Also inhibits ATP citrate lyase

Fluorescent amyloid β detector; brain penetrant

Mcl-1 inhibitor; proapoptotic

Binds mot-2; selectively cytotoxic in cancer cells

Selective TRPC4 blocker

Apelin receptor (APJ) antagonist

HIF pathway activator

Activator of TRPML channels

Selective negative allosteric modulator of group II mGlu receptors

Cyclooxygenase-inhibiting nitric oxide donor

NAADP antagonist; inhibits Ca²⁺ release

Irreversible mitochondrial respiratory complex II inhibitor

Potent K_Ca3.1 channel blocker

Inhibitor of MT1-MMP; antitumor

Reversible photoactive TRPA1 activator

Potent and selective GlyT2 inhibitor

USP7 inhibitor

Potent antagonist of α_vβ₃-vitronectin interaction; antiangiogenic

TLR2/6 agonist; induces TNF-α production

Biotinylated Pam2CSK4 (Cat. No. 4637)

TLR1/2 agonist; induces cytokine production

Biotinylated Pam3CSK4 (Cat. No. 4633)

Reversible inhibitor of MKLP-2

Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)

Potent, selective Cdk4/6 inhibitor; brain penetrant

Aurora kinase A and B inhibitor

Potent and selective EP₂ receptor antagonist

Dual PI 3-K/mTOR inhibitor

Potent and selective Na_V1.8 channel blocker; active in vivo

Potent and selective dual PI 3-kinase/mTOR inhibitor

Potent inhibitor of interleukin-2 inducible T cell kinase (ITK). Also inhibits BTK

Positive allosteric modulator of AMPA

Inhibits TRPP3-mediated currents; also inhibits epithelial Na⁺ channels

Induces G₂/M cell cycle arrest; anticancer

Inhibitor of SCD1; selectively eliminates undifferentiated hPSCs from culture

Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

Negative allosteric modulator of 5-HT₃

Negative allosteric modulator at PAR₁ receptor

5-HT₂/D₂ antagonist; atypical antipsychotic

5-HT_2C inverse agonist; α₂ antagonist

Potent FAAH inhibitor

Urotensin-II (UT) antagonist; attenuates cardiac dysfunction

Potent MSK1 inhibitor; also inhibits other AGC group kinases

Highly potent and selective DOT1L inhibitor; cell permeable

Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

Inhibits Smoothened (Smo) accumulation

TRPV1 antagonist; displays in vivo activity

Potent NK₁ receptor antagonist

Selective α3β4 nAChR antagonist

REV-ERBα antagonist

Calcium sensing receptor (CaSR) agonist

Inhibitor of NF-kB activation; also inhibits SXC

Nrf2 pathway activator; blocks Nrf2/Keap1 interaction

Potent, high affinity CB₁ receptor inverse agonist

GPR35 agonist; more potent than zaprinast (Cat. No. 0947)

Selective melanin-concentrating hormone receptor 1 (MCH₁R) antagonist

Constitutive androstane receptor (CAR) agonist

Inhibitor of IP6K; also inhibits IP3K

Potent and selective GPR120 agonist

Potent antagonist of L3MBTL3 Kme reader domain; cell permeable

Negative allosteric modulator at mGlu₅

Selective H₄ agonist

Tankyrase inhibitor; inhibits Wnt signaling

ALDH1a2 inhibitor

Potent and selective mTOR inhibitor

Na⁺/Ca²⁺ exchange inhibitor (reverse mode); neuroprotective

Cdc42 inhibitor