All Products

Cat.No.

Product Name / Activity

Highly potent, selective PDE5 inhibitor

Potent liver X receptor (LXR) agonist; also CAR inverse agonist

GnRH receptor antagonist

Highly potent and selective PPARγ antagonist

Ca²⁺-activated Cl^- channel transmembrane protein 16A (TMEM16A) inhibitor

Potent, orally active ghrelin receptor agonist

GABA_A agonist. Also GABA-T substrate and GABA uptake inhibitor

Synthetic vitamin D₃ (Cat. No. 4156) analog

Cholinesterase inhibitor

Potent and selective ErbB2 inhibitor

Potent p38 MAPK inhibitor; anti-inflammatory

CaCC blocker and Cl^-/HCO₃^- exchange)

Potent, selective inhibitor of noradrenalin transporters

Selective inhibitor of noradrenalin transporters

Synthetic thyrotropin-releasing hormone (TRH) analog

Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination

Estrogen receptor partial agonist/antagonist

Selective α_1A antagonist

Selective 5-HT_1A partial agonist

Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties

Nrf2 pathway activator; blocks Nrf2/Keap1 interaction

Non-selective, endogenous glycine receptor partial agonist

Promotes assembly and inhibits disassembly of microtubules

Receptor-selective retinoid; binds RAR-β and -γ

α5-selective GABA_A inverse agonist

Selective cell-permeable CK2 inhibitor

Selective non-transportable inhibitor of EAATs

High affinity σ₁ ligand

CXCR4 antagonist; CXCR7 agonist

α7-selective agonist

Selective partial agonist at α4β2 receptors

Potent and selective 17β-hydroxysteroid dehydrogenase type 3 inhibitor

Potent, selective Aurora kinase A inhibitor

Potent, high affinity 5-HT_2A agonist

Potent, high affinity CB₁ receptor inverse agonist

Potent and selective inhibitor of DAPK1

Potent, reversible and selective FAAH inhibitor

Potent and selective GSK-3β inhibitor

Class I histone deacetylase inhibitor

Selective melanin-concentrating hormone receptor 1 (MCH₁R) antagonist

Selective Na_V1.7 blocker

Selective NR1/NR2A receptor antagonist

NMDA antagonist; selective for NR2A over NR2B

Potent, selective mGlu₄ positive allosteric modulator

Highly potent and selective NR2B antagonist

Positive allosteric modulator of mGlu₄

Potent and selective GPR139 agonist

Selective P2X₃, P2X_2/3 antagonist

Constitutive androstane receptor (CAR) agonist

Potent, dual orexin receptor antagonist

GABA_A α2 benzodiazepine receptor agonist

Subtype-selective GABA_A receptor agonist

Fragment 1-13 of GSK-3β sequence

Scrambled control peptide for use with TCS 183 (Cat. No. 2236)

Potent GSK-3β inhibitor

Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC

Inducer of neuronal differentiation in MSCs

Potent Chk1 inhibitor

α₄β₁ (VLA-4) antagonist

Selective EP₄ agonist

Potent FLT3 inhibitor

Selective inhibitor of PTP1B

Orally active, subtype-selective NR1A/NR2B antagonist

TRPA1 blocker

Potent and selective ERK2 inhibitor

Selective inhibitor of JNK2 and JNK3

Selective JNK inhibitor

Potent and selective OX₂ antagonist

Selective, ATP-competitive Pim-1 kinase inhibitor

Selective, ATP-competitive Pim kinase inhibitor

Antiprion agent; potently inhibits PrP-res accumulation

Potent S1P₁ receptor agonist

5-, 12-, 15-Lipoxygenase inhibitor

5-HT₄ partial agonist

Potent CCR2b antagonist

Potent, selective M₁ antagonist

DNA-methylating antitumor agent

Superoxide scavenger; antioxidant

NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of K_IR2.3

Reverse transcriptase inhibitor

Protects against MDM2-mediated p53 degradation

α₁ and α_2B antagonist (α₁ > α_2B). Orally active

H₁ antagonist. Also K_V11.1 (hERG) and K_ir6 (K_ATP) channel blocker

Selective inhibitor of BTK

Selective K_ir1.1 blocker; derivative of tertiapin-Q (Cat. No. 1316)

Selective blocker of inward-rectifier K⁺ channels

PPARα/γ agonist

Endogenous androgen receptor agonist

Potent inhibitor of vesicular monoamine transport

Non-selective K⁺ channel blocker

Highly potent NMDA receptor agonist

MAO-A inhibitor

Na⁺ channel blocker

Na⁺ channel blocker. Citrate salt of tetrodotoxin (Cat. No. 1078)

High affinity EAAT1 and EAAT2 blocker

PAR₁-activating peptide

Selective androgen receptor modulator (SARM)

Potent, ATP-competitive inhibitor of Clk-family kinases

PI 3-kinase inhibitor

TNF-α synthesis inhibitor

Potent inhibitor of SERCA ATPase

Potent subtype-selective ligand; ERα agonist/ERβ antagonist

Glutamate receptor ligand

Adenosine receptor antagonist; bronchodilator

Potent O-GlcNAcase inhibitor

Improves the efficiency of fibroblast reprogramming and induction of iPSCs

Anticancer and immunosuppressive agent

Bacterial RNA polymerase inhibitor

H₃ antagonist and H₄ inverse agonist

Dopamine receptor antagonist; antipsychotic

Antibiotic, inhibits protein synthesis

Potent and selective P2Y₂ agonist

GABA_A agonist

Potent and selective MC₄ receptor agonist

Causes platelet aggregation and secretion

Potent actin polymerization regulator

GABA uptake inhibitor; anticonvulsant

Selective facilitator of 5-HT uptake; antidepressant

Selective P2Y₁₂ antagonist

β₁ antagonist

Heme oxygenase inhibitor

Potent, selective H₂ antagonist

α₂ agonist

VGF-derived peptide

Dual-kinase inhibitor; inhibits CK2 and ERK8

Cyclophilin A inhibitor

Neuronal nicotinic receptor antagonist

Inhibitor of human telomerase

Cytochrome P450 1B1 inhibitor

Inhibitor of IP6K; also inhibits IP3K

Potent, selective P2X antagonist

Novel fluorescent cannabinoid ligand. Fluorescent form of AM 251 (Cat. No. 1117)

80 kinase inhibitors supplied pre-dissolved in DMSO (250μl 10mM solutions)

1120 biologically active compounds pre-dissolved in DMSO (50μl 10mM solutions)

1120 biologically active compounds pre-dissolved in DMSO (250μl 10mM solutions)

Water-soluble emulsion; negative control for reagents in Tocrisolve^TM 100

Potent, non-selective muscarinic receptor antagonist

Potent, selective noradrenalin re-uptake inhibitor

GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

Inhibitor of cholesteryl ester transfer protein (CETP)

Potent and selective mTOR inhibitor

Potent and selective mTOR inhibitor

Functionally selective GABA_A receptor (α3 subtype) partial agonist

Potent, selective inhibitor of IKKβ

Cell-permeable Zn²⁺ chelator

Selective GABA_C antagonist

Positive allosteric modulator of α7 nAChRs

Subtype-selective GABA_A allosteric modulator

Highly selective K_Ca3.1 channel blocker

Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog

Antiallergic, inhibits release from mast cells

Irreversible inhibitor of MAO-A, MAO-B and LSD1

Potent and selective NOP antagonist

PAR₁ peptide fragment (residues 42-47); acts as a PAR₁ agonist

Potent and selective FP prostaglandin receptor agonist

Extremely potent inhibitor of PDE3

Histone deacetylase inhibitor

Thymidylate synthase inhibitor; induces DNA fragmentation

nNOS/iNOS inhibitor

Aryl hydrocarbon receptor antagonist

Standard H₁ antagonist, highly potent

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Commonly used laboratory reagent

Commonly used laboratory reagent

Potent, selective inhibitor of mitotic kinesin Eg5

Binds voltage-dependent anion channel (VDAC)

Selective PPARγ agonist; antidiabetic agent

5-HT₃ antagonist

Selective M₄ muscarinic antagonist

Potent 5-HT₃ receptor antagonist; orally active

Antibiotic; inhibits bacterial DNA synthesis

sst₁/sst₄ somatostatin receptor agonist

Retinoic acid analog; RAR agonist

High affinity, selective CK2 inhibitor

HDAC 6 inhibitor; inhibits α-tubulin deacetylation

Nicotinic receptor antagonist

FFA1 (GPR40) agonist

Potent and selective GPR120 agonist

Antibiotic; GlcNAc phosphotransferase inhibitor

Bcl-2 inhibitor; induces apoptosis

GSK-3β inhibitor; induces neuronal differentiation in ESCs

EGFR-kinase inhibitor

EGFR-kinase inhibitor