All Products

Cat.No.

Product Name / Activity

Antibody recognizing STAT3

Highly potent 5-HT_1A agonist; displays unique binding mechanism

Potent and selective NPY Y₅ antagonist

Selective GABA_B antagonist

Cell-permeable inhibitor of eIF2α dephosphorylation

β agonist (β₂ > β₁)

Potent β₂ agonist; long acting

Endogenous amino acid

Selective inhibitor of eIF2α dephosphorylation

Highly potent and selective κ-opioid agonist

AMP-activated protein kinase substrate

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

Endothelin receptor agonist

Endothelin receptor agonist, non-selective

Selective ET_B agonist

Non-selective angiotensin II antagonist

GlyT1 inhibitor

Selective 5-HT_2A antagonist

CRF agonist

α4β2 receptor ligand; may act as an agonist or a desensitizer

5-HT_2C/2B antagonist

Potent, selective inhibitor of p38 MAPK

5-HT₄ antagonist

Selective inhibitor of p38 MAPK

Selective inhibitor of p38 MAPK; water-soluble

Potent, selective 5-HT_2B antagonist

GABA_A receptor modulator; slows current decay

δ₁ selective, high affinity non-peptide agonist

Potent, selective 5-HT_2C/5-HT_2B antagonist. Orally active

Selective h5-HT_1B antagonist

Potent, selective GSK-3 inhibitor

Inhibitor of checkpoint kinase 1 (Chk1)

Potent, selective non-peptide NK₃ antagonist

Potent, selective 5-HT_2C/2B antagonist

Potent, selective non-peptide NK₃ antagonist. Brain penetrant

Selective 5-HT_1B antagonist

Potent and selective CXCR2 antagonist

5-HT_2C/2B antagonist/inverse agonist

Potent, selective p38 MAP kinase inhibitor; orally active

Selective 5-HT_2C antagonist; brain penetrant

Potent, selective 5-HT₆ antagonist

Selective 5-HT₇ antagonist

Potent CXCR2 antagonist

Potent selective 5-HT₇ antagonist. Brain penetrant

Orally active, selective 5-HT₆ antagonist

Potent and selective CCR3 antagonist

Selective non-peptide OX₁ antagonist

Potent, selective, competitive TRPV1 (VR1) antagonist

Potent and selective 5-HT₆ antagonist

Selective non-peptide OX₁ antagonist

Potent, selective GSK-3 inhibitor

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Selective inhibitor of TGF-βRI

Selective urotensin-II (UT) receptor antagonist

Selective 5-ht_5A antagonist

Selective EP₁ receptor antagonist

Selective EP₁ receptor antagonist

IKK-2 inhibitor; attenuates NF-κB-induced gene expression

Cyclooxygenase (COX-1) inhibitor

Selective inhibitor of LTA₄ hydrolase

Selective cyclooxygenase-2 (COX-2) inhibitor

Protein kinase C activator

Protein kinase C activator

Inhibitor of ligand binding to G-protein-coupled receptors

Standard selective D₁-like antagonist. Also 5-HT_2C agonist

H⁺,K⁺-ATPase inhibitor

High affinity D₁/D₅ receptor antagonist

Very selective, high affinity A_2A antagonist

Selective, competitive, orally active GABA_B antagonist

Potent, highly selective A_2A antagonist

Potent, selective non-peptide PAR₁ antagonist

Non-selective muscarinic antagonist

Histone deacetylase inhibitor

Selective GABA_A receptor antagonist; β1-subunit-selective

Selective, orally active p38α inhibitor

Potent ATP-competitive TGF-βRI inhibitor

Potent, selective non-peptide δ antagonist

5-HT₄/5-HT₃ receptor antagonist

β-adrenoceptor antagonist. Also 5-HT_1A/1B antagonist

Potent, competitive NMDA antagonist

Competitive NMDA antagonist

Highly selective, human NK₁ antagonist

Selective 5-HT_2B/2C antagonist

Potent, selective A₁ agonist

Sec7-specific GEF inhibitor (cytohesins)

Gastrointestinal peptide

Gastrointestinal peptide

sst₂ and sst₅ agonist

Tachykinin NK₃ agonist

Potent, selective CB₂ agonist

Potentiator, acts glycine site

Weak endogenous glycine receptor agonist

Endogenous 5-HT receptor agonist

Selection of 4 serotonin uptake inhibitors (Cat. Nos. 1427, 0457, 0927 and 1033)

5-HT re-uptake inhibitor

Cell-permeable, selective S1P₁ receptor agonist

K⁺ channel opener; vasodilator

MC₃ and MC₄ antagonist, MC₅ partial agonist

Highly selective mGlu₅ antagonist

mGlu₅ antagonist and positive allosteric modulator at mGlu₄

5-HT and noradrenalin re-uptake inhibitor (SNRI)

Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor

PDE3 inhibitor

Orally active, potent PDE4 inhibitor

HMG-CoA reductase inhibitor

Water-soluble NO donor

Selective sirtuin family deacetylase inhibitor

Selective leukocyte elastase inhibitor

σ₁ selective agonist

Activator of K_Ca3.1 and K_Ca2 channels

Selective D₁-like agonist

Selective D₁-like partial agonist

D₁ agonist

Potent, selective D₁-like antagonist

Selective D₁-like agonist

D₁-like partial agonist

p38 MAP kinase inhibitor; anti-inflammatory agent

Potent GABA uptake inhibitor. Penetrates blood brain barrier

Histamine N-methyltransferase inhibitor

STIM1-mediated Ca²⁺ influx inhibitor

Extremely potent GABA_B agonist

Selective non-lipid inhibitor of sphingosine kinase; antitumor

Selective p90 ribosomal S6 kinase (RSK) inhibitor

Selective inhibitor of MEK1 and MEK2; brain penetrant

PAR₂ receptor agonist

PAR₂-activating peptide

Potent and selective A₁ antagonist

Presynaptic cholinergic modulator

DNA topoisomerase I inhibitor; antitumor

Selective Na⁺/Ca²⁺ exchange inhibitor (reverse mode)

A stable analog of endogenous S-nitroso compounds

Subtype-selective α_1A antagonist

GABA uptake inhibitor

Potent and selective MCH₁ antagonist

Highly selective non-peptide δ agonist. Analog of Cat. No. 0764

Potent, selective non-peptide δ agonist

Highly selective non-peptide δ agonist

NO carrier. Breaks down to release NO

Potent and selective Ca_V2.3 blocker (R-type)

Commonly used laboratory reagent

Commonly used laboratory reagent

Protein tyrosine phosphatase inhibitor

Influences growth hormone release

Somatostatin receptor agonist

β antagonist

Novel and selective JNK inhibitor

Selective mGlu₃ agonist

Selective NK₁ antagonist

Agonist at polyamine site

Modulator at polyamine site

Slow NO releasing agent

Protein kinase C inhibitor

Endogenous agonist at S1P_1-5

Potent P2X₃ antagonist

5-HT_2A antagonist. Also D₂-like antagonist

Mineralocorticoid receptor antagonist

Potent α_2C antagonist

Sir2p inhibitor

Adenylyl cyclase inhibitor

Inhibitor of AP-1 transcription factor; antitumor agent

Pregnane X receptor (PXR) agonist

Highly potent NT receptor antagonist

Selective PPARγ antagonist; antidiabetic and antiobesity agent

Potent, selective LTD₄ /LTE₄ receptor antagonist

Potent and selective CCK₁ antagonist

Ca²⁺ channel blocker; binds allosterically to distinct site on L-type channels

Selective, orally active vasopressin V_1A receptor antagonist

Potent, selective 5-HT₃ agonist

Potent and selective β₃ antagonist

Selective, competitive GABA_A receptor antagonist

Dual site Src kinase inhibitor

Potent, orally active human leukocyte elastase inhibitor

α₂ agonist, putative α_2C agonist

Aldose reductase inhibitor

Selective STAT3 inhibitor

Inhibits NME2 nuclear translocation; primes ESCs for differentiation

Non-selective protein kinase inhibitor

Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors

Selective CaM kinase kinase inhibitor

DNA alkylator; antitumor and induces diabetes

CRF₁ agonist

Competitive glycine receptor antagonist

Potent and selective PDGFRβ inhibitor

Selective JNK inhibitor

Potent inhibitor of VEGFR tyrosine kinase

Potent FGFR and VEGFR inhibitor

VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

PDGFR, VEGFR and FGFR inhibitor

Potent cdk2 inhibitor

Sensory neuropeptide, inflammatory mediator

Potent ghrelin receptor full inverse agonist. Also antagonist at other neuropeptide receptors. Anticancer in vitro

Inhibits M₁ ACh receptor activation of G_q/11

Potent, selective NK₁ agonist

Endothelin ET_A antagonist

Group I agonist

Cyclooxygenase inhibitor (following metabolism to sulindac sulfide)

Standard selective D₂-like antagonist

Standard selective D₂-like antagonist

5-HT₁ receptor agonist

Non-peptide calcitonin (CT) receptor agonist

Potent VEGFR, PDGFRβ and KIT inhibitor

Th2 cytokine synthesis inhibitor; antiasthmatic

Non-selective P2 antagonist

Inhibitor of α-mannosidase II

Highly selective kainate agonist

Non-competitive AMPA antagonist

Non-competitive NMDA antagonist