R&D Systems Inc. Tocris Bioscience Boston Biochem

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Displaying products alphabetically by name (S)

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Cat.No.
Product Name / Activity
1771S 14506 hydrochloride

Highly potent 5-HT1A agonist; displays unique binding mechanism

3911S 18986

Positive allosteric modulator of AMPA

3518S 24795

Partial agonist at α7 nAChR

3432S 25585

Potent and selective NPY Y5 receptor antagonist

4508S 32212 hydrochloride

5-HT2C inverse agonist; α2 antagonist

3404S 32826

Potent autotaxin inhibitor

3690S26948

Selective PPARγ agonist; antidiabetic agent

0246Saclofen

Selective GABAB antagonist

4652SAHA

Class I and II HDAC inhibitor

3657Sal 003

Cell-permeable inhibitor of eIF2α dephosphorylation

0634Salbutamol hemisulfate

β agonist (β2 > β1)

4127Salermide

SIRT1 and SIRT2 inhibitor

4712Salmeterol xinafoate

Long-acting β2 agonist; bronchodilator

0636Salsolinol-1-carboxylic acid

Endogenous amino acid

2347Salubrinal

Selective inhibitor of eIF2α dephosphorylation

2134Salvinorin A

Highly potent and selective κ-opioid agonist

1344SAMS Peptide

AMP-activated protein kinase substrate

2302Sanguinarine chloride

Inhibitor of protein phosphatase 2C (PP2C)

1974SANT-1

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

3617SANT-2

Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity

4418Saquinavir mesylate

HIV protease inhibitor

1899Sarafotoxin S6a

Endothelin receptor agonist

1174Sarafotoxin S6b

Endothelin receptor agonist, non-selective

1175Sarafotoxin S6c

Selective ETB agonist

1163Saralasin

Non-selective angiotensin II antagonist

2975Sarcosine

GlyT1 inhibitor

3739Sarpogrelate hydrochloride

Selective 5-HT2A antagonist

1609Sauvagine

CRF agonist

2736Sazetidine A dihydrochloride

α4β2 receptor ligand; may act as an agonist or a desensitizer

1371SB 200646 hydrochloride

5-HT2C/2B antagonist

1264SB 202190

Potent, selective inhibitor of p38 MAPK

0785SB 203186 hydrochloride

5-HT4 antagonist

1202SB 203580

Selective inhibitor of p38 MAPK

1402SB 203580 hydrochloride

Selective inhibitor of p38 MAPK; water-soluble

1373SB 204070

Potent and selective 5-HT4 antagonist

1372SB 204741

Potent, selective 5-HT2B antagonist

1512SB 205384

GABAA receptor modulator; slows current decay

0921SB 205607 dihydrobromide

δ1 selective, high affinity non-peptide agonist

1661SB 206553 hydrochloride

Potent, selective 5-HT2C/5-HT2B antagonist. Orally active

1242SB 216641 hydrochloride

Selective h5-HT1B antagonist

1616SB 216763

Potent, selective GSK-3 inhibitor

2560SB 218078

Inhibitor of checkpoint kinase 1 (Chk1)

1376SB 218795

Potent, selective non-peptide NK3 antagonist

1379SB 221284

Potent, selective 5-HT2C/2B antagonist

1393SB 222200

Potent, selective non-peptide NK3 antagonist. Brain penetrant

1221SB 224289 hydrochloride

Selective 5-HT1B antagonist

2725SB 225002

Potent and selective CXCR2 antagonist

1375SB 228357

5-HT2C/2B antagonist/inverse agonist

1962SB 239063

Potent, selective p38 MAPK inhibitor; orally active

2901SB 242084

Selective 5-HT2C antagonist; brain penetrant

3527SB 243213 dihydrochloride

Selective 5-HT2C inverse agonist

1961SB 258585 hydrochloride

Potent, selective 5-HT6 antagonist

2726SB 258719 hydrochloride

Selective 5-HT7 antagonist

2724SB 265610

Potent CXCR2 antagonist

4314SB 268262

Selective non-peptide CGRP1 antagonist

1612SB 269970 hydrochloride

Potent selective 5-HT7 antagonist. Brain penetrant

3368SB 271046 hydrochloride

Orally active, selective 5-HT6 antagonist

4207SB 277011A dihydrochloride

Selective D3 antagonist

4213SB 297006

Potent and selective CCR3 antagonist

3650SB 328437

Potent and selective CCR3 antagonist

1960SB 334867

Selective non-peptide OX1 antagonist

1615SB 366791

Potent, selective, competitive TRPV1 (VR1) antagonist

3189SB 399885 hydrochloride

Potent and selective 5-HT6 antagonist

1963SB 408124

Selective non-peptide OX1 antagonist

1617SB 415286

Potent, selective GSK-3 inhibitor

1614SB 431542

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

3265SB 452533

Potent TRPV1 receptor antagonist

3263SB 505124

Selective inhibitor of TGF-βRI, ALK4 and ALK7

3211SB 525334

Selective inhibitor of TGF-βRI

2650SB 590885

Potent B-Raf inhibitor

4670SB 611812

Urotensin-II (UT) antagonist; attenuates cardiac dysfunction

3573SB 612111 hydrochloride

Selective NOP receptor antagonist

3571SB 657510

Selective urotensin-II (UT) receptor antagonist

3188SB 699551

Selective 5-ht5a antagonist

4118SB 772077B dihydrochloride

Potent Rho-kinase inhibitor; vasodilator

4292SBE 13 hydrochloride

Potent and selective PLK1 inhibitor

3810SBHA

Histone deacetylase inhibitor

1206SC 19220

Selective EP1 receptor antagonist

4189SC 26196

Selective Δ6 desaturase inhibitor

3758SC 51089

Selective EP1 receptor antagonist

2791SC 51322

Potent EP1 receptor antagonist

3318SC 514

IKKβ inhibitor; attenuates NF-κB-induced gene expression

1550SC 560

Cyclooxygenase (COX-1) inhibitor

3107SC 57461A

Selective inhibitor of LTA4 hydrolase

2895SC 58125

Selective cyclooxygenase-2 (COX-2) inhibitor

3919SC 236

Selective cyclooxygenase-2 (COX-2) inhibitor

4398SC 66

Allosteric Akt inhibitor

0430SC-10

Protein kinase C activator

0433SC-9

Protein kinase C activator

1400SCH 202676 hydrobromide

Inhibitor of ligand binding to G-protein-coupled receptors

3240SCH 221510

Potent and selective NOP agonist

0925SCH 23390 hydrochloride

Standard selective D1-like antagonist. Also 5-HT2C agonist

1690SCH 28080

H+,K+-ATPase inhibitor

2299SCH 39166 hydrobromide

High affinity D1/D5 receptor antagonist

2463SCH 442416

Very selective, high affinity A2A antagonist

0984SCH 50911

Selective, competitive, orally active GABAB antagonist

2270SCH 58261

Potent, highly selective A2A antagonist

1592SCH 79797 dihydrochloride

Potent, selective non-peptide PAR1 antagonist

3528SCIO 469 hydrochloride

Selective p38 MAPK inhibitor

1414Scopolamine hydrobromide

Non-selective muscarinic antagonist

2421Scriptaid

Histone deacetylase inhibitor

2143SCS

Selective GABAA receptor antagonist; β1-subunit-selective

3035SD 1008

JAK2/STAT3 signaling pathway inhibitor

3269SD 208

Potent ATP-competitive TGF-βRI inhibitor

1410SDM25N hydrochloride

Potent, selective non-peptide δ antagonist

2037SDZ 205-557 hydrochloride

5-HT4/5-HT3 receptor antagonist

1516SDZ 21009

β-adrenoceptor antagonist. Also 5-HT1A/1B antagonist

1251SDZ 220-040

Potent, competitive NMDA antagonist

1250SDZ 220-581

Competitive NMDA antagonist

2394SDZ NKT 343

Highly selective, human NK1 antagonist

1255SDZ SER 082 fumarate

Selective 5-HT2B/2C antagonist

2465SDZ WAG 994

Potent, selective A1 agonist

2849SecinH3

Sec7-specific GEF inhibitor (cytohesins)

1918Secretin (human)

Gastrointestinal peptide

1919Secretin (rat)

Gastrointestinal peptide

1836Seglitide

sst2 and sst5 agonist

4441SEN 12333

α7 nAChR agonist; histamine H3 antagonist

1068Senktide

Tachykinin NK3 agonist

3556SER 601

Potent, selective CB2 agonist

0226D-Serine

Potentiator, acts glycine site

0227L-Serine

Weak endogenous glycine receptor agonist

3547Serotonin hydrochloride

Endogenous 5-HT receptor agonist

1877Serotonin Uptake Inhibitor Tocriset™

Selection of 4 serotonin uptake inhibitors (Cat. Nos. 1427, 0457, 0927 and 1033)

2395Sertraline hydrochloride

5-HT re-uptake inhibitor

2284SEW 2871

Cell-permeable, selective S1P1 receptor agonist

3898SF 11

NPY Y2 receptor antagonist

4541SGC 0946

Highly potent and selective DOT1L inhibitor; cell permeable

3688SGS 518 oxalate

Selective 5-HT6 antagonist

4510SHA 68

Selective neuropeptide S receptor antagonist

3420SHU 9119

MC3 and MC4 antagonist, MC5 partial agonist

1215SIB 1757

Highly selective mGlu5 antagonist

1214SIB 1893

mGlu5 antagonist and positive allosteric modulator at mGlu4

2290Sibutramine hydrochloride

5-HT and noradrenalin re-uptake inhibitor (SNRI)

3625SID 26681509

Cathepsin L inhibitor

3440SID 7969543

Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor

1148Siguazodan

PDE3 inhibitor

3784Sildenafil citrate

Orally active, potent PDE5 inhibitor

1965Simvastatin

HMG-CoA reductase inhibitor

0756SIN-1 chloride

Water-soluble NO donor

3848Sinomenine hydrochloride

Anti-inflammatory; causes mast cell degranulation and histamine release

4044Sipatrigine

NaV blocker; neuroprotective

3521Sirtinol

Selective sirtuin family deacetylase inhibitor

3535Sivelestat sodium salt

Selective leukocyte elastase inhibitor

3929SJ 172550

MDMX inhibitor. Disrupts MDMX-p53 interaction

1079(+)-SK&F 10047 hydrochloride

σ1 selective agonist

3711SK1-I

Sphingosine kinase 1 (SphK1) inhibitor; antiproliferative

3670SKA 31

Activator of KCa3.1 and KCa2 channels

0922SKF 38393 hydrobromide

Selective D1-like agonist

1662SKF 77434 hydrobromide

Selective D1-like partial agonist

1447SKF 81297 hydrobromide

D1 agonist

1586SKF 83566 hydrobromide

Potent, selective D1-like antagonist

2075SKF 83822 hydrobromide

Selective D1-like agonist

2074SKF 83959 hydrobromide

D1-like partial agonist

2008SKF 86002 dihydrochloride

p38 MAPK inhibitor; anti-inflammatory agent

3866SKF 86466 hydrochloride

Potent and selective α2 antagonist

1081SKF 89976A hydrochloride

Potent GABA uptake inhibitor. Penetrates blood brain barrier

0512SKF 91488 dihydrochloride

Histamine N-methyltransferase inhibitor

1147SKF 96365 hydrochloride

TRPC channel blocker; also inhibits store-operated Ca2+ entry

0379SKF 97541

Extremely potent GABAB agonist

2097SKI II

Selective non-lipid inhibitor of sphingosine kinase

4817SKPin C1

Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

2250SL 0101-1

Selective p90 ribosomal S6 kinase (RSK) inhibitor

1969SL 327

Selective inhibitor of MEK1 and MEK2; brain penetrant

3010SLIGKV-NH2

PAR2 receptor agonist

1468SLIGRL-NH2

PAR2-activating peptide

3344SLV 320

Potent and selective A1 antagonist

0751SM-21 maleate

Presynaptic cholinergic modulator

4662SMANT hydrochloride

Inhibits Smoothened (Smo) accumulation

4297SMER 28

Positive regulator of autophagy

4375SMER 3

Specific inhibitor of E3 ubiquitin ligase

4401SMIFH2

FH2 domain inhibitor; prevents actin nucleation

3294SN 003

Potent and selective CRF1 antagonist

2684SN 38

DNA topoisomerase I inhibitor; antitumor

2184SN-6

Selective Na+/Ca2+ exchange inhibitor (reverse mode)

0598SNAP

A stable analog of endogenous S-nitroso compounds

2398SNAP 5089

Subtype-selective α1A antagonist

1561(S)-SNAP 5114

GABA uptake inhibitor

3347SNAP 94847 hydrochloride

Potent and selective MCH1 antagonist

1529SNC 162

Potent, selective non-peptide δ agonist

0764SNC 80

Highly selective non-peptide δ agonist

0603SNOG

NO carrier. Breaks down to release NO

4075SNS 032

Potent cdk2, cdk7 and cdk9 inhibitor

2945SNX 482

Potent and selective CaV2.3 blocker (R-type)

3159Sodium acetate

Commonly used laboratory reagent

3152Sodium bicarbonate

Commonly used laboratory reagent

3850Sodium butyrate

Histone deacetylase inhibitor

3146Sodium chloride

Commonly used laboratory reagent

3161Sodium citrate

Commonly used laboratory reagent

2821Sodium orthovanadate

Protein tyrosine phosphatase inhibitor

1157Somatostatin

Influences growth hormone release

1165Somatostatin 1-28

Somatostatin receptor agonist

4185Sonepiprazole

Selective D4 receptor antagonist

0952Sotalol hydrochloride

β antagonist

1496SP 600125

Novel and selective JNK inhibitor

0391Spaglumic acid

Selective mGlu3 agonist

1784Spantide I

Selective NK1 antagonist

0959Spermidine trihydrochloride

Agonist at polyamine site

0958Spermine tetrahydrochloride

Modulator at polyamine site

1135Spermine NONOate

Slow NO releasing agent

0633D-erythro-Sphingosine (synthetic)

Protein kinase C inhibitor

1370Sphingosine-1-phosphate

Endogenous agonist at S1P1-5

4729α-Spinasterol

TRPV1 antagonist; displays in vivo activity

2931Spinorphin

Potent P2X3 antagonist

0995Spiperone hydrochloride

5-HT2A antagonist. Also D2-like antagonist

2968Spironolactone

Mineralocorticoid receptor antagonist

0631Spiroxatrine

Potent α2C antagonist

1542Splitomicin

Sir2p inhibitor

1435SQ 22536

Adenylyl cyclase inhibitor

3411SR 11237

Pan RXR agonist

2476SR 11302

Inhibitor of AP-1 transcription factor; antitumor agent

2969SR 12813

Pregnane X receptor agonist

4012SR 140333

Potent NK1 receptor antagonist

0923SR 141716A

Selective CB1 receptor antagonist

2309SR 142948

Highly potent NT receptor antagonist

4424SR 16584

Selective α3β4 nAChR antagonist

4409SR 1664

High affinity PPARγ ligand; blocks Cdk5-dependent PPARγ phosphorylation

2022SR 202

Selective PPARγ antagonist; antidiabetic and antiobesity agent

1804SR 2640 hydrochloride

Potent, selective LTD4 /LTE4 receptor antagonist

2190SR 27897

Potent and selective CCK1 antagonist

1806SR 33805 oxalate

Ca2+ channel blocker; binds allosterically to distinct site on L-type channels

3667SR 3677 dihydrochloride

Potent, selective Rho-kinase (ROCK) inhibitor

3721SR 48692

Selective nonpeptide NTS1 antagonist

2310SR 49059

Selective, orally active vasopressin V1A receptor antagonist

1205SR 57227 hydrochloride

Potent, selective 5-HT3 agonist

3986SR 58611A hydrochloride

β3 agonist; displays anxiolytic and antidepressant effects

1511SR 59230A hydrochloride

Potent and selective β3 antagonist

4463SR 8278

REV-ERBα antagonist

1262SR 95531 hydrobromide

Selective, competitive GABAA receptor antagonist

3642Src I1

Dual site Src kinase inhibitor

3297SSR 146977 hydrochloride

Potent and selective NK3 antagonist

2506SSR 69071

Potent, orally active human leukocyte elastase inhibitor

4337ST 1936 oxalate

Selective, high affinity 5-HT6 agonist

2638ST 91

α2 agonist, putative α2C agonist

2798Stattic

Selective STAT3 inhibitor

3741Stauprimide

Inhibits NME2 nuclear translocation; primes ESCs for differentiation

1285Staurosporine

Non-selective protein kinase inhibitor

2204STEARDA

Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors

4509STF 083010

Inhibits IRE1α endonuclease activity

4484STF 31

GLUT1 inhibitor

1551STO-609 acetate

Selective CaM kinase kinase inhibitor

1621Streptozocin

DNA alkylator; antitumor and induces diabetes

1608Stressin I

CRF1 agonist

4749Strontium chloride

Calcium sensing receptor (CaSR) agonist

4101SU 11274

Selective inhibitor of MET kinase activity

3304SU 16f

Potent and selective PDGFRβ inhibitor

3607SU 3327

Selective JNK inhibitor

1459SU 4312

Potent inhibitor of VEGFR tyrosine kinase

3300SU 5402

Potent FGFR and VEGFR inhibitor

3037SU 5416

VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

3335SU 6668

PDGFR, VEGFR and FGFR inhibitor

2907SU 9516

Potent cdk2 inhibitor

1156Substance P

Sensory neuropeptide, inflammatory mediator

1946[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

Potent ghrelin receptor full inverse agonist. Also antagonist at other neuropeptide receptors. Anticancer in vitro

1884[D-Trp7,9,10]-Substance P

Inhibits M1 ACh receptor activation of Gq/11

1178[Sar9,Met(O2)11]-Substance P

Potent, selective NK1 agonist

0731Sulfisoxazole

Endothelin ETA antagonist

0162S-Sulfo-L-cysteine sodium salt

Group I agonist

1707Sulindac

Cyclooxygenase inhibitor (following metabolism to sulindac sulfide)

0894(RS)-(±)-Sulpiride

Standard selective D2-like antagonist

0895(S)-(-)-Sulpiride

Standard selective D2-like antagonist

3049Sulprostone

EP3 and EP1 receptor agonist

2773Sumanirole maleate

D2-selective agonist

3586Sumatriptan

5-HT1A/1B/1D receptor agonist

2550SUN-B 8155

Non-peptide calcitonin (CT) receptor agonist

3768Sunitinib malate

Potent VEGFR, PDGFRβ and KIT inhibitor

3543Suplatast tosylate

Th2 cytokine synthesis inhibitor; antiasthmatic

1472Suramin hexasodium salt

Non-selective P2 antagonist

3208Swainsonine

Inhibitor of α-mannosidase II

3639SX 011

p38 MAPK inhibitor

0903SYM 2081

Highly selective kainate agonist

0961SYM 2206

Non-competitive AMPA antagonist

0635Synthalin sulfate

Non-competitive NMDA antagonist

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The Role of Cytokines and Signaling in Inflammation

October 15, 2013

Bonn, Germany