All Products

Cat.No.

Product Name / Activity

Highly potent 5-HT_1A agonist; displays unique binding mechanism

Positive allosteric modulator of AMPA

Partial agonist at α7 nAChR

Potent and selective NPY Y₅ receptor antagonist

5-HT_2C inverse agonist; α₂ antagonist

Potent autotaxin inhibitor

Selective PPARγ agonist; antidiabetic agent

Selective GABA_B antagonist

Class I and II HDAC inhibitor

Cell-permeable inhibitor of eIF2α dephosphorylation

β agonist (β₂ > β₁)

SIRT1 and SIRT2 inhibitor

Long-acting β₂ agonist; bronchodilator

Endogenous amino acid

Selective inhibitor of eIF2α dephosphorylation

Highly potent and selective κ-opioid agonist

AMP-activated protein kinase substrate

Inhibitor of protein phosphatase 2C (PP2C)

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity

HIV protease inhibitor

Endothelin receptor agonist

Endothelin receptor agonist, non-selective

Selective ET_B agonist

Non-selective angiotensin II antagonist

GlyT1 inhibitor

Selective 5-HT_2A antagonist

CRF agonist

α4β2 receptor ligand; may act as an agonist or a desensitizer

5-HT_2C/2B antagonist

Potent, selective inhibitor of p38 MAPK

5-HT₄ antagonist

Selective inhibitor of p38 MAPK

Selective inhibitor of p38 MAPK; water-soluble

Potent and selective 5-HT₄ antagonist

Potent, selective 5-HT_2B antagonist

GABA_A receptor modulator; slows current decay

δ₁ selective, high affinity non-peptide agonist

Potent, selective 5-HT_2C/5-HT_2B antagonist. Orally active

Selective h5-HT_1B antagonist

Potent, selective GSK-3 inhibitor

Inhibitor of checkpoint kinase 1 (Chk1)

Potent, selective non-peptide NK₃ antagonist

Potent, selective 5-HT_2C/2B antagonist

Potent, selective non-peptide NK₃ antagonist. Brain penetrant

Selective 5-HT_1B antagonist

Potent and selective CXCR2 antagonist

5-HT_2C/2B antagonist/inverse agonist

Potent, selective p38 MAPK inhibitor; orally active

Selective 5-HT_2C antagonist; brain penetrant

Selective 5-HT_2C inverse agonist

Potent, selective 5-HT₆ antagonist

Selective 5-HT₇ antagonist

Potent CXCR2 antagonist

Selective non-peptide CGRP₁ antagonist

Potent selective 5-HT₇ antagonist. Brain penetrant

Orally active, selective 5-HT₆ antagonist

Selective D₃ antagonist

Potent and selective CCR3 antagonist

Potent and selective CCR3 antagonist

Selective non-peptide OX₁ antagonist

Potent, selective, competitive TRPV1 (VR1) antagonist

Potent and selective 5-HT₆ antagonist

Selective non-peptide OX₁ antagonist

Potent, selective GSK-3 inhibitor

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Potent TRPV1 receptor antagonist

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Selective inhibitor of TGF-βRI

Potent B-Raf inhibitor

Urotensin-II (UT) antagonist; attenuates cardiac dysfunction

Selective NOP receptor antagonist

Selective urotensin-II (UT) receptor antagonist

Selective 5-ht_5a antagonist

Potent Rho-kinase inhibitor; vasodilator

Potent and selective PLK1 inhibitor

Histone deacetylase inhibitor

Selective EP₁ receptor antagonist

Selective Δ6 desaturase inhibitor

Selective EP₁ receptor antagonist

Potent EP₁ receptor antagonist

IKKβ inhibitor; attenuates NF-κB-induced gene expression

Cyclooxygenase (COX-1) inhibitor

Selective inhibitor of LTA₄ hydrolase

Selective cyclooxygenase-2 (COX-2) inhibitor

Selective cyclooxygenase-2 (COX-2) inhibitor

Allosteric Akt inhibitor

Protein kinase C activator

Protein kinase C activator

Inhibitor of ligand binding to G-protein-coupled receptors

Potent and selective NOP agonist

Standard selective D₁-like antagonist. Also 5-HT_2C agonist

H⁺,K⁺-ATPase inhibitor

High affinity D₁/D₅ receptor antagonist

Very selective, high affinity A_2A antagonist

Selective, competitive, orally active GABA_B antagonist

Potent, highly selective A_2A antagonist

Potent, selective non-peptide PAR₁ antagonist

Selective p38 MAPK inhibitor

Non-selective muscarinic antagonist

Histone deacetylase inhibitor

Selective GABA_A receptor antagonist; β1-subunit-selective

JAK2/STAT3 signaling pathway inhibitor

Potent ATP-competitive TGF-βRI inhibitor

Potent, selective non-peptide δ antagonist

5-HT₄/5-HT₃ receptor antagonist

β-adrenoceptor antagonist. Also 5-HT_1A/1B antagonist

Potent, competitive NMDA antagonist

Competitive NMDA antagonist

Highly selective, human NK₁ antagonist

Selective 5-HT_2B/2C antagonist

Potent, selective A₁ agonist

Sec7-specific GEF inhibitor (cytohesins)

Gastrointestinal peptide

Gastrointestinal peptide

sst₂ and sst₅ agonist

α7 nAChR agonist; histamine H₃ antagonist

Tachykinin NK₃ agonist

Potent, selective CB₂ agonist

Potentiator, acts glycine site

Weak endogenous glycine receptor agonist

Endogenous 5-HT receptor agonist

Selection of 4 serotonin uptake inhibitors (Cat. Nos. 1427, 0457, 0927 and 1033)

5-HT re-uptake inhibitor

Cell-permeable, selective S1P₁ receptor agonist

NPY Y₂ receptor antagonist

Highly potent and selective DOT1L inhibitor; cell permeable

Selective 5-HT₆ antagonist

Selective neuropeptide S receptor antagonist

MC₃ and MC₄ antagonist, MC₅ partial agonist

Highly selective mGlu₅ antagonist

mGlu₅ antagonist and positive allosteric modulator at mGlu₄

5-HT and noradrenalin re-uptake inhibitor (SNRI)

Cathepsin L inhibitor

Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor

PDE3 inhibitor

Orally active, potent PDE5 inhibitor

HMG-CoA reductase inhibitor

Water-soluble NO donor

Anti-inflammatory; causes mast cell degranulation and histamine release

Na_V blocker; neuroprotective

Selective sirtuin family deacetylase inhibitor

Selective leukocyte elastase inhibitor

MDMX inhibitor. Disrupts MDMX-p53 interaction

σ₁ selective agonist

Sphingosine kinase 1 (SphK1) inhibitor; antiproliferative

Activator of K_Ca3.1 and K_Ca2 channels

Selective D₁-like agonist

Selective D₁-like partial agonist

D₁ agonist

Potent, selective D₁-like antagonist

Selective D₁-like agonist

D₁-like partial agonist

p38 MAPK inhibitor; anti-inflammatory agent

Potent and selective α₂ antagonist

Potent GABA uptake inhibitor. Penetrates blood brain barrier

Histamine N-methyltransferase inhibitor

TRPC channel blocker; also inhibits store-operated Ca²⁺ entry

Extremely potent GABA_B agonist

Selective non-lipid inhibitor of sphingosine kinase

Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

Selective p90 ribosomal S6 kinase (RSK) inhibitor

Selective inhibitor of MEK1 and MEK2; brain penetrant

PAR₂ receptor agonist

PAR₂-activating peptide

Potent and selective A₁ antagonist

Presynaptic cholinergic modulator

Inhibits Smoothened (Smo) accumulation

Positive regulator of autophagy

Specific inhibitor of E3 ubiquitin ligase

FH2 domain inhibitor; prevents actin nucleation

Potent and selective CRF₁ antagonist

DNA topoisomerase I inhibitor; antitumor

Selective Na⁺/Ca²⁺ exchange inhibitor (reverse mode)

A stable analog of endogenous S-nitroso compounds

Subtype-selective α_1A antagonist

GABA uptake inhibitor

Potent and selective MCH₁ antagonist

Potent, selective non-peptide δ agonist

Highly selective non-peptide δ agonist

NO carrier. Breaks down to release NO

Potent cdk2, cdk7 and cdk9 inhibitor

Potent and selective Ca_V2.3 blocker (R-type)

Commonly used laboratory reagent

Commonly used laboratory reagent

Histone deacetylase inhibitor

Commonly used laboratory reagent

Commonly used laboratory reagent

Protein tyrosine phosphatase inhibitor

Influences growth hormone release

Somatostatin receptor agonist

Selective D₄ receptor antagonist

β antagonist

Novel and selective JNK inhibitor

Selective mGlu₃ agonist

Selective NK₁ antagonist

Agonist at polyamine site

Modulator at polyamine site

Slow NO releasing agent

Protein kinase C inhibitor

Endogenous agonist at S1P_1-5

TRPV1 antagonist; displays in vivo activity

Potent P2X₃ antagonist

5-HT_2A antagonist. Also D₂-like antagonist

Mineralocorticoid receptor antagonist

Potent α_2C antagonist

Sir2p inhibitor

Adenylyl cyclase inhibitor

Pan RXR agonist

Inhibitor of AP-1 transcription factor; antitumor agent

Pregnane X receptor agonist

Potent NK₁ receptor antagonist

Selective CB₁ receptor antagonist

Highly potent NT receptor antagonist

Selective α3β4 nAChR antagonist

High affinity PPARγ ligand; blocks Cdk5-dependent PPARγ phosphorylation

Selective PPARγ antagonist; antidiabetic and antiobesity agent

Potent, selective LTD₄ /LTE₄ receptor antagonist

Potent and selective CCK₁ antagonist

Ca²⁺ channel blocker; binds allosterically to distinct site on L-type channels

Potent, selective Rho-kinase (ROCK) inhibitor

Selective nonpeptide NTS₁ antagonist

Selective, orally active vasopressin V_1A receptor antagonist

Potent, selective 5-HT₃ agonist

β3 agonist; displays anxiolytic and antidepressant effects

Potent and selective β₃ antagonist

REV-ERBα antagonist

Selective, competitive GABA_A receptor antagonist

Dual site Src kinase inhibitor

Potent and selective NK₃ antagonist

Potent, orally active human leukocyte elastase inhibitor

Selective, high affinity 5-HT₆ agonist

α₂ agonist, putative α_2C agonist

Selective STAT3 inhibitor

Inhibits NME2 nuclear translocation; primes ESCs for differentiation

Non-selective protein kinase inhibitor

Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors

Inhibits IRE1α endonuclease activity

GLUT1 inhibitor

Selective CaM kinase kinase inhibitor

DNA alkylator; antitumor and induces diabetes

CRF₁ agonist

Calcium sensing receptor (CaSR) agonist

Selective inhibitor of MET kinase activity

Potent and selective PDGFRβ inhibitor

Selective JNK inhibitor

Potent inhibitor of VEGFR tyrosine kinase

Potent FGFR and VEGFR inhibitor

VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

PDGFR, VEGFR and FGFR inhibitor

Potent cdk2 inhibitor

Sensory neuropeptide, inflammatory mediator

Potent ghrelin receptor full inverse agonist. Also antagonist at other neuropeptide receptors. Anticancer in vitro

Inhibits M₁ ACh receptor activation of G_q/11

Potent, selective NK₁ agonist

Endothelin ET_A antagonist

Group I agonist

Cyclooxygenase inhibitor (following metabolism to sulindac sulfide)

Standard selective D₂-like antagonist

Standard selective D₂-like antagonist

EP₃ and EP₁ receptor agonist

D₂-selective agonist

5-HT_1A/1B/1D receptor agonist

Non-peptide calcitonin (CT) receptor agonist

Potent VEGFR, PDGFRβ and KIT inhibitor

Th2 cytokine synthesis inhibitor; antiasthmatic

Non-selective P2 antagonist

Inhibitor of α-mannosidase II

p38 MAPK inhibitor

Highly selective kainate agonist

Non-competitive AMPA antagonist

Non-competitive NMDA antagonist