All Products

Cat.No.

Product Name / Activity

Highly potent, selective GSK-3 inhibitor

High affinity retinol-binding protein 4 (RBP4) ligand

Selective inhibitor of E-selectin and ICAM-1 expression

Potent inhibitor of the LFA-1/ICAM-1 interaction

Soluble guanylyl cyclase (sGC) activator

Selective D₄ agonist

Inhibitor of Src family kinases

Competitve P2X₇ antagonist

CaM kinase III (eEF-2 kinase) inhibitor

Partial agonist at α7 nAChR

α_1A agonist

Potent, selective D₁-like agonist

Potent and selective P2X₇ antagonist

Potent AMPK activator

Potent, selective D₁-like agonist. Orally active

Potent and selective TRPV1 antagonist

Selective Na_V1.8 blocker

High affinity α₂ antagonist. Also 5-HT uptake inhibitor

Potent and selective P2X₇ antagonist

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Potent P2X₇ antagonist

Selective mGlu₁ antagonist

Selective α7 nAChR agonist

Positive allosteric modulator of α7 nAChR

Potent voltage-dependent Na_V1.8 channel blocker

Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor

Potent and selective H₄ antagonist

Selective TRPA1 channel blocker

Potent and selective H₄ receptor antagonist

Calcium ionophore

Calmodulin antagonist

Potent and selective CCK₁ agonist. Suppresses feeding

Thromboxane A₂ (TP) receptor antagonist

Positive allosteric modulator of GABA_A receptors

Phospholipase A₂ inhibitor

Selective Hsp90 inhibitor

Selective GPR55 agonist; neurobehaviorally inactive

Adenosine kinase inhibitor; orally active

Potent, selective D₄ partial agonist; proerectile

Inhibitor of microtubule polymerization; antimitotic and antitumor

Potent and selective amylin receptor antagonist

RARβ2 agonist

PAR₂ receptor agonist

SF-1 inverse agonist

Potent and selective PAR₂ agonist

Selective RARβ2 agonist

Non-peptide UT receptor agonist

Chloride transport inhibitor

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

Annexin I N-terminal peptide. Acts as a FPR1 ligand

GABA agonist and glutamatergic modulator

Glucosidase α inhibitor (intestinal)

NMDA antagonist, acts at glycine site

Potent, selective L-glutamate uptake inhibitor

Selective mGlu₅ receptor antagonist

Potent, highly selective CB₁ agonist

Anticholinesterase insecticide

Potent antagonist of GluR5-containing kainate receptors

Cyclooxygenase inhibitor; may be selective for COX-3

Nitroxyl precursor

Intermediate in lipid metabolism

Endogenous neurotransmitter

Nicotinic agonist

Potent convulsant

Cathepsin inhibitor

Nicotinic agonist

Phosphopeptide ligand for src SH2 domain

Phosphopeptide ligand for src SH2 domain

Melatonin partial agonist (MT₁/MT₂). Also MT₃ antagonist

Selective IKKα and IKKβ inhibitor

Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors

Antilipolytic agent

Potent, selective CB₁ agonist

Potent, selective CB₁ agonist (in water-soluble emulsion)

Group I/group II mGlu agonist

Potent NMDA agonist. Also group II mGluR agonist

Group I/group II mGlu agonist

Group III mGlu agonist

Competitive mGlu receptor antagonist

Artificial cerebrospinal fluid

Potent endogenous MC₂ agonist

Inhibits RNA polymerase

α9α10-selective antagonist

Inhibits viral DNA polymerase; antiherpetic agent

RARβ and RARγ agonist

p210^bcr/abl kinase inhibitor

Adenine receptor agonist

Endogenous adenosine receptor agonist

Potent and selective K_V1.3 channel blocker

Negative allosteric modulator at mGlu₅

Inhibitor of JNK signaling

Potent, selective human type I IL-1 receptor antagonist

Selective M₂ antagonist

Potent M₂/M₄ antagonist

Selective GnRH receptor antagonist

Highly potent EGFR-kinase inhibitor

EGFR/PDGFR-kinase inhibitor

EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor

Potent EGFR-kinase inhibitor

Potent EGFR-kinase inhibitor

EGFR-kinase inhibitor

Selective ErbB2 inhibitor

TrkA inhibitor

EGFR-kinase inhibitor

Ca²⁺ channel blocker (P-type)

Ca²⁺ channel blocker (P/Q-type)

Selective SIRT2 inhibitor

α₂ ligand. Also imidazoline ligand

I₁ selective ligand

Subtype-selective α_1B ligand

EP₁ and EP₂ receptor antagonist

AMPK activator

Potent, selective group I mGlu antagonist

Antagonist; preferential action at D₂-like autoreceptors

Selective SIRT2 inhibitor; brain penetrant

Akt/PKB substrate (synthetic)

Akt/PKB substrate (synthetic)

Endogenous glycine agonist, more selective than taurine (Cat. No. 0209)

Glycine receptor agonist

Antiproliferative; induces activin/SMAD3 signaling

ALDH2 activator; cardioprotective

Selective inhibitor of PTPMT1

Prodrug of vitamin D₃ (Cat. No. 4156)

Uroselective α₁ antagonist

GABA_A receptor positive allosteric modulator

Selection of 5 α₁-adrenoceptor ligands (Cat. Nos. 1052, 0888, 1006, 0946 and 0623)

Selection of 5 α₂-adrenoceptor ligands (Cat. Nos. 1030, 0425, 0928, 1133 and 0891)

Direct activator and potentiator of GABA_A

β antagonist

Prostaglandin. Vasodilator and antiplatelet agent in vivo

Aldose reductase inhibitor

5-HT_2A receptor antagonist

Selective non-transportable GlyT1 inhibitor

Amphibian bombesin-like peptide

20S proteasome inhibitor

Anandamide uptake inhibitor. Also FAAH inhibitor and CB receptor partial agonist

Potent CB₁ antagonist. Also GPR55 agonist

Potent, selective CB₁ antagonist/inverse agonist

Anandamide transport inhibitor

Anandamide transport inhibitor (in water-soluble emulsion)

Retinoic acid analog; RARα agonist

CB₂ selective antagonist/inverse agonist

RARα agonist; anticancer

K_V channel blocker

Inhibitor of RNA polymerase II

Cholinesterase inhibitor

Na⁺ channel blocker

Highly selective CXCR4 antagonist

Potent, selective CXCR4 antagonist

Potent and selective p38α inhibitor

Potent and selective, competitive antagonist of TRPV1

D₂-like receptor antagonist

Na⁺ channel blocker. Also I₂ imidazoline ligand

Adenine receptor agonist

PARP inhibitor

Irreversible iNOS inhibitor

H₂ antagonist

Cyclin-dependent kinase inhibitor

Non-selective K_V channel blocker

Broad spectrum ion channel blocker; antiarrhythmic

Selective D₂/D₃ receptor antagonist; atypical antipsychotic agent

5-HT and noradrenalin re-uptake inhibitor

Inhibitor of TBK1 and IKKε; antiallergic agent

Ca²⁺ channel blocker (L-type)

The first selective mGlu₇ agonist

Selective AMPA agonist. More water soluble form of (RS)-AMPA (Cat. No. 0169)

Selection of 5 AMPA receptor ligands (Cat. Nos. 0254, 0306, 1044, 0713 and 1454)

Inactive isomer of (RS)-AMPA (Cat. No. 0169)

Selective AMPA agonist

Selective AMPA agonist. Active isomer of (RS)-AMPA (Cat. No. 0169)

Atypical antipsychotic; high affinity 5-HT₂ ligand

Induces dopamine, 5-HT and noradrenalin release

cAMP antagonist

Cell-permeable cAMP analog

Potent, selective iNOS inhibitor

TRPM8 blocker

Highly selective standard H₂ agonist

Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors

Inactive control peptide for amyloid β-peptide (1-42) (Cat. No. 1428)

Amyloid β-peptide; substrate for MMP-2

Amyloid β-peptide; minimum required for binding to brain proteins

Amyloid β-protein fragment

Amyloid β-protein fragment

Predominant amyloid β-protein fragment

Predominant amyloid β-protein fragment

Amyloid β-protein fragment

Human amyloid β-protein fragment functionally required for neurotoxicity

TrkB receptor antagonist

Neuronal nicotinic receptor agonist

Noncompetitive PCAF/p300 HAT inhibitor

Potent PDE3 inhibitor

Endogenous CB receptor agonist

Endogenous CB receptor agonist (in water-soluble emulsion)

Deuterated anandamide. Endogenous CB receptor agonist

Potent aromatase (CYP19) inhibitor

Nicotinic agonist

Inhibits NFκB; blocks androgen receptor (AR) expression

Vasorelaxant peptide

Endogenous precursor to angiotensin II (Cat. No. 1158)

Potent vasoconstrictor peptide

Vasoconstrictor peptide

Desensitization inhibitor (AMPA > kainate)

Activates JNK/SAPK/p38 MAP kinase

Highly potent 5-HT_1B agonist. Also 5-HT₃ antagonist

Adenosine A_2A antagonist

Broad spectrum neuropeptide receptor antagonist

CRF₁ antagonist

Imidazoline ligand

Potent, selective and competitive CRF₂ antagonist

Reversible TRPA1 channel blocker

Potent multi-kinase and pan-BCR-ABL inhibitor

Group I mGlu antagonist

Broad spectrum EAA antagonist. Sodium salt of DL-AP4 (Cat. No. 0101)

Broad spectrum EAA antagonist

Broad spectrum EAA antagonist

Selective group III mGlu agonist

Sodium salt of DL-AP5 (Cat. No. 0105)

Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105)

Potent, selective NMDA antagonist

Potent, selective NMDA antagonist. Less active form of DL-AP5 (Cat. No. 0105)

Selective agonist of the 'quis' effect

Specific NMDA antagonist. More active form of DL-AP7 (Cat. No. 0104)

Specific NMDA antagonist

K_Ca2 channel blocker (small conductance)

IP₃ receptor antagonist. Also TRP channel modulator

Tryptase inhibitor

Highly selective group II agonist

Potent peptide agonist for APJ receptor

Endogenous APJ receptor agonist

Endogenous APJ receptor agonist

Endogenous APJ receptor agonist

ASIC3 channel blocker

Selective Akt/PKB inhibitor. Antitumor

Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral

Selective group II antagonist

Histone deacetylase inhibitor

Protein kinase inhibitor

NADPH-oxidase inhibitor

Dopamine agonist; non-subtype-selective

Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

5-HT₃ antagonist

Selective, high affinity M₂ antagonist

Selective GSK-3 inhibitor

Endogenous free fatty acid (in water-soluble emulsion)

Potent, competitive MAGL inhibitor

Dual FAAH inhibitor/TRPV1 antagonist

Inhibits pain in vivo

Endogenous cannabinoid agonist

Novel endocannabinoid. Suppresses pain in vivo

Selective iNOS inhibitor

α_2B antagonist

Potent and selective P2Y₁₂ antagonist

Competitive NMDA antagonist

Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation

Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)

Muscarinic agonist

Muscarinic agonist

Potent thrombin inhibitor

Endogenous substrate for NOS

Selective nNOS inhibitor

Ecto-ATPase inhibitor

Low-internalizing δ opioid receptor agonist

GAL₂ agonist

Selective inhibitor of MMP-2

Inhibitor of MMP-2

α7-selective agonist

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum

Potent CB₁ and TRPV1 agonist. Also anandamide transport inhibitor

Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release

GPR119 receptor agonist

Reported potent 5-HT₇ agonist

SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor

Selective inhibitor of PI 3-kinase γ

Potent and selective PI 3-kinase γ (PI3Kγ) inhibitor

Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631)

Enhances the generation of iPSCs; increases reprogramming efficiency

Novel antipsychotic agent

NMDA agonist

NMDA agonist

Cyclooxygenase inhibitor; NSAID

Orally active, potent H₁ antagonist. Also K_V11.1 (hERG) channel blocker.

Potent CRF receptor antagonist

Selective CRF₂ antagonist

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

Long-acting 5-HT_2A antagonist

L-PGDS inhibitor

Potent and selective MCH₁ antagonist

MCH₁ antagonist; also 5-HT_2B antagonist and 5-HT_1A partial agonist

β₁ antagonist

β₁-antagonist. Active isomer of atenolol (Cat. No. 0387)

Selective α₂ antagonist

HMG-CoA reductase inhibitor

P2 agonist

Selective, potent GluR5 agonist

P2 agonist; ATP (Cat. No. 3245) analog

Endogenous peptide regulating blood pressure

Endogenous peptide regulating blood pressure

Thioredoxin reductase inhibitor; induces MPT

Selective CaM kinase II inhibitor

Potent and selective human V_1B agonist

Potent VEGFR-1, -2 and -3 inhibitor

Inhibitor of Hedgehog (Hh) signaling. Inhibits Δ⁷-dehydrocholesterol reductase

Selective PAR₄ agonist

Selective non-peptide caspase-3 inhibitor

Potent P2X₇ receptor antagonist

Potent and selective human P2X₇ antagonist

Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor

DNA methyltransferase inhibitor

Purine analog; prodrug of 6-mercaptopurine (Cat. No. 4103)

Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor

Potent AT₁ receptor inverse agonist; antihypertensive

Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation

Src tyrosine kinase inhibitor