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IWP 2

Cat No. 3533

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Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4- oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

Biological Activity

Inhibitor of Wnt processing and secretion. Inactivates Porcn, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation.

Technical Data

M.Wt:

466.6

Formula:

C₂₂H₁₈N₄O₂S₃

Solubility:

Soluble to 10 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

[686770-61-6]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

_Chen_{et
al (2009) Small molecule-mediated disruption of wnt-dependent signaling in
tissue regeneration and cancer. Nature Chem.Biol. 5 100.}

If you know of a useful citation for this product please let us know.

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Keywords: IWP 2, MBOAT, membrane-bound, o-acyltransferases, Porcupine, porcn, wnt, secretion, production, signaling, signalling, inhibitors, inactivators, inactivates, IWP2