R&D Systems Inc. Tocris Bioscience Boston Biochem

IWP 2

Cat. No. 3533

IWP 2 C22H18N4O2S3 [686770-61-6]

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Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

Biological Activity

Inhibitor of Wnt processing and secretion. Inactivates Porcn, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. Suppresses self-renewal in R1 embryonic stem cells.

Technical Data

M.Wt:
466.6
Formula:
C22H18N4O2S3
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
686770-61-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Chen et al (2009) Small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer. Nature Chem.Biol. 5 100. PMID: 19125156.

ten Berge et al (2011) Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat.Cell.Biol. 13 1070. PMID: 21841791.

Lian et al (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc.Natl.Acad.Sci.U S A 109 E1848. PMID: 22645348.

If you know of a relevant citation for this product please let us know.

Keywords: IWP 2, supplier, MBOAT, membrane-bound, o-acyltransferases, Porcupine, porcn, wnt, secretion, production, signaling, signalling, inhibitors, inactivators, inactivates, IWP2, beta-catenin, β-catenin, b-catenin, stem, cell, proliferation

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