Endothelin 1 (human, porcine)

Cat. No. 1160

Endothelin 1 (human, porcine) Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-lle-Ile-Trp (Disulfide bridges: 1 - 15, 3 - 11)

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Alternative Name: ET-1

Biological Activity

Endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone.

Technical Data


(Modifications: Disulfide bridge between 1 - 15, 3 - 11)

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Yanagisawa et al (1988) Primary structure, synthesis, and biological activity of rat endothelin, and endothelium-derived vasoconstrictor peptide. Proc.Natl.Acad.Sci.U.S.A. 85 6964. PMID: 3045827.

Inoue et al (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 86 2863. PMID: 2649896.

Yanagisawa and Masaski (1989) Molecular biology and biochemistry of the endothelins. TiPS 10 374. PMID: 2690429.

Servitja et al (1998) Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 124 1728. PMID: 9756390.

If you know of a relevant citation for this product please let us know.

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Keywords: Endothelin 1 (human, porcine), supplier, Potent, vasoconstrictor, peptide, Endothelin, Non-Selective, ET, Receptors, agonists, Endothelin1, (human, porcine), Non-selective Endothelin Agonists

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