R&D Systems Inc. Tocris Bioscience Boston Biochem

Endothelin 1 (human, porcine)

Cat. No. 1160

Endothelin 1 (human, porcine) Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-lle-Ile-Trp (Disulfide bridges: 1 - 15, 3 - 11)

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Alternative Name: ET-1

Biological Activity

Endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone.

Technical Data

M.Wt:
2492
Formula:
C109H159O32N25S5
Sequence:
CSCSSLMDKECVYFCHLDIIW

(Modifications: Disulfide bridge between 1 - 15, 3 - 11)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
117399-94-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Yanagisawa et al (1988) Primary structure, synthesis, and biological activity of rat endothelin, and endothelium-derived vasoconstrictor peptide. Proc.Natl.Acad.Sci.U.S.A. 85 6964. PMID: 3045827.

Inoue et al (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 86 2863. PMID: 2649896.

Yanagisawa and Masaski (1989) Molecular biology and biochemistry of the endothelins. TiPS 10 374. PMID: 2690429.

Servitja et al (1998) Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 124 1728. PMID: 9756390.

If you know of a relevant citation for this product please let us know.

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Keywords: Endothelin 1 (human, porcine), supplier, Potent, vasoconstrictor, peptide, Endothelin, Non-Selective, ET, Receptors, agonists, Endothelin1, (human, porcine)

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