Doxazosin | Adrenergic Receptors | A1-adrenoceptor Antagonist | UK 33274

Category:

7TM Receptors

Adrenergic Receptors

Alpha-1 Receptors

Antagonists

Cat.No.

Product Name

2964

Doxazosin mesylate

Alternative name(s):

UK 33274

Doxazosin C23H25N5O5.CH3SO3H 4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate

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Doxazosin

Chemical Name: 4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl ]-6,7-dimethoxyquinazoline methanesulfonate

Biological Activity:

Selective α₁-adrenoceptor antagonist (pK_i values are 9.0, 8.5 and 8.4 for human α_1B, α_1A and α_1D receptors respectively). Displays antihypertensive activity.

Technical Data:

M.Wt:	547.58
Formula:	C₂₃H₂₅N₅O₅.CH₃SO₃H
Storage:	Desiccate at RT
Solubility:	Soluble to 75 mM in DMSO
Purity:	>99%
CAS No:	[77883-43-3]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Alabaster and Davey (1986) The α₁-adrenoceptor antagonist profile of doxazosin: preclinical pharmacology. Br.J.Clin.Pharmacol. 21 9S. Kenny et al (1996) Evaluation of the pharmacological selectivity profile of α₁ adrenoceptor antagonists at prostatic α₁ adrenoceptors: binding functional and in vivo studies. Br.J.Pharmacol. 118 871. Ma et al (2006) Chiral selective effects of doxazosin enantiomers on blood pressure and urinaruy bladder pressure in anesthetized rats. Acta Pharmacol.Sinica 27 1423.

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Keywords: Doxazosin, Adrenergic Receptors, A1-adrenoceptor Antagonist, UK 33274, Tocris Bioscience

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Adrenoceptor Pharmacology
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