Solubility information for any product can be found on the respective product page of our website and the corresponding Certificate of Analysis (CoA) / Safety Data Sheet (SDS).
Most peptides are soluble in distilled water. If they do not completely dissolve, the addition of 1.0 M acetic acid for basic peptides (those containing Arg, Lys, His), or 1.0 M ammonium hydroxide for acidic peptides (those containing Asp, Glu) may help. Solubilization of extremely insoluble peptides can be assisted with 10% DMSO or DMF, although the use of these may interfere with some biological assays. Sonication can also be a useful aid. It is recommended that the peptide be dissolved to the highest possible concentration and then diluted with water or buffer to the working concentration. Buffer should only be added when the peptide is completely dissolved as salts may otherwise cause aggregation.
Tocrisets consist of 3-5 key ligands supplied as lyophilized solids, or pre-dissolved in DMSO at a specific concentration. Detailed solubility instructions, including suitable solvents, are provided in the Tocriset booklet. This can also be downloaded as a PDF.
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