Scientific Reviews

A range of review articles written by leading experts

Tocris produces a range of short review articles written by leading experts summarizing the most recent developments in research and available products. We invite you to request or download your copy today.

5-HT Receptors

Nicholas M. Barnes and John F. Neumaier

This review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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Cannabinoid Receptor Ligands

Roger G Pertwee, University of Aberdeen

Two types of cannabinoid receptor have so far been identified. This review focuses particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

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Dopamine Receptors

Phillip G. Strange, University of Reading

A summary of the history of the dopamine receptor subtypes and a guide to the ligands that act upon them. Compounds available from Tocris are listed.

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GABA Receptors

Ian Martin, Norman Bowery & Susan Dunn

A review of the structure and function of GABA receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.

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Histamine Receptors

Iwan de Esch and Rob Leurs, Vrije University

This review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.

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MAPK Signaling

Elma Zaganjor and Melanie H. Cobb, University of Texas Southwestern Medical Center

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer research. This review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

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Metabotropic Glutamate Receptors

Francine C Acher, Université René Descartes-Paris V

Glutamate is the major excitatory amino acid transmitter in the brain. This review explains the pharmacology of mGlu receptors and the compounds acting upon them, listing those mGlu compounds available from Tocris.

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Nicotinic ACh Receptors

Susan Wonnacott and Jacques Barik, University of Bath

Nicotinic AChRs are ionotropic receptors stimulated by nicotine and acetylcholine. This review provides a brief overview of receptor structure and distribution, focusing primarily on the ligands available for the study of nAChRs; listing those available from Tocris.

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P2X and P2Y Receptors

Kenneth A. Jacobson, National Institutes of Health

A review of the subtypes and structures of P2 receptor families and the pharmacological probes used to study them. Compounds available from Tocris are listed.

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Peptides Involved in Appetite Modulation

Sonia A. Tucci, Lynsay Kobelis and Tim C. Kirkham, University of Liverpool

A synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis. Outlines the putative roles of most of the known players and list compounds available from Tocris.

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Pharmacology of Retinoid Receptors

Alexander R. Moise, University of Kansas

A summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaing. Compounds available from Tocris are listed.

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Stem Cell Growth and Differentiation

Victoria B. Christie and Stefan A. Przyborski, Durham University

An overview of the small molecules used to control stem cell growth and differentiation, including those involved in somatic cell reprogramming and control of pathways which modulate stem cell activity. Compounds available from Tocris are listed.

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Forthcoming Reviews:

Autophagy

Available April 2012

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Archived Reviews:

Reviews published between 1999 and 2003 have been scheduled for updating and are not in current use. Nonetheless we are pleased to provide PDF copies for download upon request.