Zolpidem | Ligand-gated Ion Channels | Benzodiazepine Agonist

Category:

Cat.No.	Product Name
0655	Zolpidem

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Zolpidem

Other Information:

This is a controlled substance with associated conditions of supply; the relevent licence/documentation from the appropriate governing body will be required.

Chemical Name: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin e-3-acetamide

Biological Activity:

Benzodiazepine agonist with high selectivity for α1-subunit-containing GABA_A receptors (BZ/ω₁ site) and very high intrinsic activity. K_i values are 20, 400 and ³ 5000 nM for α1-, α2-/α3-, and α5-containing GABA_A receptors respectively. Hypnotic that does not induce physical dependence.

Technical Data:

M.Wt:	307.39
Formula:	C₁₉H₂₁N₃O
Storage:	Store at RT
Solubility:	Soluble to 100 mM in 1eq. NaOH and to 100 mM in Ethanol
Purity:	>99%
CAS No:	[82626-48-0]

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References:

Arbilla et al (1986) High affinity [³H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 130 257. Depoortere et al (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 237 649. Perrault et al (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. J.Pharmacol.Exp.Ther. 263 298. Crestani et al (2000) Mechanism of action of the hypnotic zolpidem in vivo. Br.J.Pharmacol. 131 1251.

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Keywords: Zolpidem, Ligand-gated Ion Channels, Benzodiazepine Agonist, Tocris Bioscience

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