ZM 449829 | Kinases | Potent, Selective Jak3 Inhibitor | ZM449829

Category:

Cat.No.	Product Name
1366	ZM 449829

Price and Availability

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ZM 449829

Other Information:

Sold with the permission of AstraZeneca Ltd

Chemical Name: 1-(2-Naphthalenyl)-2-propen-1-one

Biological Activity:

Potent, selective inhibitor of Janus tyrosine kinase 3 (Jak3) which binds competitively to the Jak3 ATP site. pIC₅₀ values are 6.8, 5.0, 4.7, and < 5.0 for Jak3, EGFR, Jak1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T-cell proliferation.

Technical Data:

M.Wt:	182.22
Formula:	C₁₃H₁₀O
Storage:	Desiccate at -20°C
Purity:	>98%
CAS No:	[4452-06-6]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors. Bioorg.Med.Chem.Lett. 10 575.

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Keywords: ZM 449829, Kinases, Potent, Selective Jak3 Inhibitor, ZM449829, Tocris Bioscience

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