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Category: EnzymesarrowKinasesarrowAurora Kinase
Cat.No. Product Name
2458 ZM 447439
Price and Availability

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ZM 447439

Other Information:

Sold with the permission of AstraZeneca UK Ltd
Chemical Name: N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazo linyl]amino]phenyl]benzamide

Biological Activity:

Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumour cells versus non-dividing cells.

Technical Data:

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M.Wt: 513.59
Formula: C29H31N5O4
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in DMSO
Purity: >99%
CAS No: [331771-20-1]

Resources:

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    References:

    Ditchfield et al (2003) Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J.Cell Bio. 161 267. Jung et al (2006) Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J.Med.Chem. 49 955. Girdler et al (2006) Validating Aurora B as an anti-cancer drug target. J.Cell Sci. 119 3664.
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    Keywords: ZM 447439, Kinases, Inhibits Aurora Kinase B, ZM447439, Tocris Bioscience
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