ZM 323881 | Receptor Tyrosine Kinases (RTKs) | Potent, Selective Inhibitor Of VEGFR-2 | ZM323881

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Cat.No.	Product Name
2475	ZM 323881 hydrochloride

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ZM 323881

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Sold with the permission of AstraZeneca UK Ltd

Chemical Name: 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methyl phenol hydrochloride

Biological Activity:

Potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC₅₀ = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC₅₀ > 50 μM). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC₅₀ = 8 nM).

Technical Data:

M.Wt:	411.86
Formula:	C₂₂H₁₈FN₃O₂.HCl
Storage:	Desiccate at +4°C
Solubility:	Soluble to 50 mM in DMSO
Purity:	>99%
CAS No:	[324077-30-7]

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References:

Whittles et al (2002) ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation 9 513. Endo et al (2003) Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J.Recept.Signal Transduct.Res. 23 239.

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Keywords: ZM 323881, Receptor Tyrosine Kinases (RTKs), Potent, Selective Inhibitor Of VEGFR-2, ZM323881, Tocris Bioscience

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