ZM 306416 | Receptor Tyrosine Kinases (RTKs) | Inhibitor Of VEGF Receptor Tyrosine Kinase | ZM306416

Category:

Cat.No.	Product Name
2499	ZM 306416 hydrochloride

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ZM 306416

Other Information:

Sold with the permission of AstraZeneca UK Ltd

Chemical Name: 4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquina zoline hydrochloride

Biological Activity:

Inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and Flt VEGF receptors (IC₅₀ values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.

Technical Data:

M.Wt:	370.21
Formula:	C₁₆H₁₃N₃O₂FCl.HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 10 mM in DMSO
Purity:	>99%
CAS No:	[690206-97-4]

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Certificate of Analysis / MSDS:

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References:

Hennequin et al (1999) Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 42 5369.

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Keywords: ZM 306416, Receptor Tyrosine Kinases (RTKs), Inhibitor Of VEGF Receptor Tyrosine Kinase, ZM306416, Tocris Bioscience

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