Chemical Name:4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]t
riazin-5-ylamino]ethyl)phenol
Biological Activity:
Potent and highly selective A2A adenosine antagonist,
with a pA2 of 9.02 for A2A receptors in guinea pig
cardiac vasculature and selectivities of 1000, 91 and 500,000 over A1,
A2B and A3 sites respectively. Active in vivo.
Poucher et al (1995) The in vitro pharmacology of ZM 241385, a
potent, non-xanthine, A2a selective adenosine receptor antagonist.
Br.J.Pharmacol. 115 1096. Poucheret al (1996)
Pharmacodynamics of ZM 241385, a potent A2a adenosine receptor
antagonist, after enteric administration in rat, cat and dog.
J.Pharm.Pharmacol. 48 601. Keddieet al (1996) In
vivo characterisation of ZM 241385, a selective adenosine A2A
receptor antagonist. Eur.J.Pharmacol. 301 107.
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