ZD 7155 Hydrochloride | Peptides (Cardiovascular) | Selective Non-peptide AT1 Antagonist | ZD7155 Hydrochloride

Category:

Cat.No.	Product Name
1211	ZD 7155 hydrochloride

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ZD 7155 hydrochloride

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Sold with the permission of AstraZeneca UK Ltd

Chemical Name: 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride

Biological Activity:

A potent and selective competitive antagonist for the angiotensin II type 1 (AT₁) receptor. Displaces [¹²⁵I]-angiotensin II binding with an IC₅₀ value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT₁ antagonist, losartan.

Technical Data:

M.Wt:	474.99
Formula:	C₂₆H₂₆N₆O.HCl
Storage:	Desiccate at +4°C
Solubility:	Soluble to 50 mM in Water and to 5 mM in Ethanol
Purity:	>99%
CAS No:	[146709-78-6]

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References:

Oldham et al (1993) Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist. Br.J.Pharmacol. 109 P136. Junggren et al (1996) Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat. J.Pharm.Pharmacol. 48 829. Veelken et al (1998) Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT₃ receptors. Br.J.Pharmacol. 125 1761.

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Keywords: ZD 7155 Hydrochloride, Peptides (Cardiovascular), Selective Non-peptide AT1 Antagonist, ZD7155 Hydrochloride, Tocris Bioscience

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