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Category:
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Enzyme-Linked Receptors Cytokine Receptors
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Cat.No.
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Product Name
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1675 |
YM 90709
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Price and Availability
Click here for full price details of
YM 90709
Other Information:
Sold with the permission of Astellas Pharma Inc.
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Chemical Name:
5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizi
no[2,3-b]quinoxaline |
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Biological Activity:
Novel,
selective inhibitor of interleukin-5 (IL-5) binding to its receptor (IC50
= 0.45-1 μM). Inhibits IL-5-prolonged eosinophil survival and
IL-5-induced tyrosine phosphorylation of Jak2 without inhibiting
GM-CSF-mediated effects. In vivo, inhibits antigen-induced eosinophil and
lymphocyte recruitment in rat airways, without affecting peripheral blood or
bone marrow leukocytes.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Morokata et al (2002)
Characterization of YM-90709 as a novel antagonist which inhibits the binding
of interleukin-5 to interleukin-5 receptor. Int.Immunopharmacol. 2
1693. Morokata et al (2004) Effect of a novel interleukin-5
receptor antagonist, YM-90709
(2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline),
on antigen-induced airway inflammation in BN rats. Int.Immunopharmacol. 4
873. Morokata et al (2005) Effect of a novel interleukin-5
receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into
the airway of BDF1 mice. Immunol.Lett. 98 161.
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View related products by Pharmacological Action
or by Research Area
Keywords: YM 90709, Cytokine Receptors, Interleukin-5 Receptor Antagonist, YM90709, Tocris Bioscience
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