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Category:
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Enzymes ProteasesOther Proteases
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Cat.No.
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Product Name
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1634 |
Y-29794 oxalate
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Price and Availability
Click here for full price details of
Y-29794
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Chemical Name:
[2-[[8-(Dimethylamino)octyl]thio]-6-(1-methylethyl)-3-p
yridinyl]-2-thienylmethanone oxalate |
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Biological Activity:
Inhibitor
of prolyl endopeptidase, a serine peptidase that may be implicated in the
biosynthesis of amyloid β-peptide. Potently inhibits rat brain
prolyl endopeptidase (Ki = 0.95 nM) in vitro, and prevents amyloid β-peptide deposition in vivo. Orally
active and brain penetrant.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Nakajima et al (1992) Y-29794 - a
non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain.
Neurosci.Lett. 141 156. Kato et al (1997)
Prevention of amyloid-like deposition by a selective prolyl endopeptidase
inhibitor, Y-29794, in senescence-accelerated mouse. J.Pharmacol.Exp.Ther. 283
328.
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View related products by Pharmacological Action
or by Research Area
Keywords: Y-29794, Proteases, Prolyl Endopeptidase Inhibitor, Y29794, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
Proteasome and NF-κB
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Proteasome & calpain inhibitor. Inhibits NF-κB activation
2637
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Immunosuppressant; inhibits NF-κB & cytokine production
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