Wortmannin | Signal Transduction | Potent, Irreversible Inhibitor Of PI 3-kinase. Also Inhibitor Of PLK1 | SL-2052

Category:

Cellular Processes and Components

Signal Transduction

Inositol and cAMP Signalling

Inositol Lipids

Cat.No.

Product Name

1232

Wortmannin

Alternative name(s):

SL-2052

Wortmannin C23H24O8 (1S,6br,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione

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Wortmannin

Chemical Name: (1S,6br,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(metho xymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,- h]-2-h]-2-benzopyran-3,6,9-trione

Biological Activity:

Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC₅₀ = 2-4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC₅₀ = 5.8 nM).

Technical Data:

M.Wt:	428.44
Formula:	C₂₃H₂₄O₈
Storage:	Desiccate at -20°C
Solubility:	Soluble to 50 mM in DMSO and to 5 mM in Ethanol
CAS No:	[19545-26-7]

Resources:

Certificate of Analysis / MSDS:

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References:

Arcaro and Wymann (1993) Wortmannin is a potent phophatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem.J. 296 297. Powis et al (1994) Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 54 2419. Schultz et al (1995) In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor wortmannin. Anticancer Res. 15 1135. Liu et al (2005) Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Chem.Biol. 12 99.

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Keywords: Wortmannin, Signal Transduction, Potent, Irreversible Inhibitor Of PI 3-kinase. Also Inhibitor Of PLK1, SL-2052, Tocris Bioscience

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