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Category:
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Cellular Processes and Components Signal TransductionCytokine and NFkB SignallingNFkB/IkB
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Cat.No.
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Product Name
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2816 |
Withaferin A
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Price and Availability
Click here for full price details of
Withaferin A
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Chemical Name:
(4b,5b,6b,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergost
a-2,24-dien-26-oic acid d-lactone |
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Biological Activity:
Steroid lactone that displays
anti-inflammatory, antitumour and antiangiogenic activity. Inhibits endothelial
cells (HUVEC) spouting in vitro (IC50 = 12 nM) and in vivo. Prevents
NF-κB activation by inhibiting activation of IKKβ.
Also inhibits chymotrypsin-like activity of the 20S proteasome.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Mohan et
al (2004) Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis 7
115. Yang et al (2007) The tumor proteasome is a primary target
for the natural anticancer compound withaferin A isolated from "Indian
Winter Cherry". Mol.Pharmacol. 71 426. Kaileh et
al (2007) Withaferin A strongly elicits IkB
kinase β hyperphosphorylation concomitant with potent inhibition of its kinase
activity. J.Biol.Chem. 282 4253.
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or by Research Area
Keywords: Withaferin A, Signal Transduction, Inhibits NF-kB Activation, Tocris Bioscience
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Literature in this Area Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
Product Feature
Proteasome and NF-κB
Key proteasome inhibitors now available from Tocris include:
1748
MG 132
Proteasome & calpain inhibitor. Inhibits NF-κB activation
2637
Gliotoxin
Immunosuppressant; inhibits NF-κB & cytokine production
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