WY 14643 | PPAR Receptors | Selective PPARa Agonist | WY14643

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Cat.No.	Product Name
1312	WY 14643

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WY 14643

Chemical Name: [[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl] thio]acetic acid

Biological Activity:

Selective PPARα agonist (EC₅₀ values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.

Technical Data:

M.Wt:	323.8
Formula:	C₁₄H₁₄ClN₃O₂S
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO
Purity:	>98%
CAS No:	[50892-23-4]

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References:

Forman et al (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and d. Proc.Natl.Acad.Sci.USA 94 4312. Bishop-Bailey (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 129 823. Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527.

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Keywords: WY 14643, PPAR Receptors, Selective PPARa Agonist, WY14643, Tocris Bioscience

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