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Category: Ion ChannelsarrowTransient Receptor Potential ChannelsarrowOther TRP Channels
Cat.No. Product Name
2927 WS 3
Price and Availability

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WS 3
Chemical Name: N-Ethyl-5-methyl-2-(1-methylethyl)cyclohexanecarboxamid e

Biological Activity:

Cooling agent that is an agonist at TRPM8 receptors (EC50 = 3.7 μM).

Technical Data:

Click here for more information on batch specific data
M.Wt: 211.34
Formula: C13H25NO
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Purity: >99%
CAS No: [39711-79-0]

Resources:

  • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Behrendt et al (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br.J.Pharmacol. 141 737. Bodding (2007) TRP proteins and cancer. Cell. Signal. 19 617. Rovner (2007) Better than mint. C&EN 85 95.
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    Keywords: WS 3, Transient Receptor Potential Channels, TRPM8 Agonist; Cooling Agent, WS3, Tocris Bioscience

    Literature in this Area
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..”
    Researcher, University of Pisa, Italy
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