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Category:
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7TM Receptors Peptides (Cardiovascular)Bradykinin Receptors
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Cat.No.
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Product Name
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1057 |
WIN 64338 hydrochloride
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Price and Availability
Click here for full price details of
WIN 64338 hydrochloride
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Chemical Name:
(S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naph
thalenyl)-1-oxopropylamino]benzyl tributyl phosphonium
chloride hydrochloride |
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Biological Activity:
The first potent, non-peptide, competitive bradykinin B2
receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin
binding on guinea pig trachea with nanomolar affinity but is not active in the
rabbit aorta (the classical bradykinin B1 preparation).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Scherrer et al (1995) Effects of WIN 64338, a nonpeptide bradykinin
B2 receptor antagonist, on guinea-pig trachea. Br.J.Pharmacol. 115
1127. Marceau et al (1994) Effects of peptide and nonpeptide
antagonists of bradykinin B2 receptors on the venoconstrictor action
of bradykinin. J.Pharmacol.Exp.Ther. 269 1136. Hu et al
(2004) Action of bradykinin in the submucosal plexus of guinea pig small
intestine. J.Pharmacol.Exp.Ther. 309 320.
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Keywords: WIN 64338 Hydrochloride, Peptides (Cardiovascular), Bradykinin B2 Antagonist, WIN64338 Hydrochloride, Tocris Bioscience
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| “I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..” Researcher, University of Pisa, Italy |
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