WAY 161503 | 5-HT Receptors | Potent, Selective 5-HT2C Agonist | WAY161503

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Cat.No.	Product Name
1801	WAY 161503 hydrochloride

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WAY 161503

Chemical Name: 8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quin oxalin-5(6H)-one hydrochloride

Biological Activity:

Potent and selective 5-HT_2C receptor agonist (K_i = 4 nM; EC₅₀ = 12 nM). Antidepressant following systemic administration in vivo.

Technical Data:

M.Wt:	308.59
Formula:	C₁₁H₁₁Cl₂N₃O.HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 10 mM in Water
Purity:	>99%
CAS No:	[75704-24-4]

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Certificate of Analysis / MSDS:

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References:

Rosenzweig-Lipson et al (2000) Antiobesity-like effects of the selective 5-HT2C agonist WAY 161503. FASEB J. 14 A1321. Welmaker et al (2000) Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg.Med.Chem.Lett. 10 1991. Cryan and Lucki (2000) Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine_2C receptors. J.Pharmacol.Exp.Ther. 295 1120.

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Keywords: WAY 161503, 5-HT Receptors, Potent, Selective 5-HT2C Agonist, WAY161503, Tocris Bioscience

Literature in this Area

Scientific Reviews

5-HT Receptors & their Ligands
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