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Category: 7TM Receptorsarrow5-HT Receptorsarrow5-HT1 Receptorsarrow5-HT1A
Cat.No. Product Name
1253 (S)-WAY 100135 dihydrochloride
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(S)-WAY 100135 dihydrochloride

Other Information:

Sold with the permission of Wyeth-Ayerst Research, US Patent 4,988,814
Chemical Name: (S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride

Biological Activity:

Potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B, 1C, 2, α1, α2 and D2 receptors (IC50 > 1000 nM). Centrally active on systemic administration.

Technical Data:

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M.Wt: 468.47
Formula: C24H33N3O2.2HCl
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in DMSO and to 100 mM in Water
Purity: >99%
CAS No: [133025-23-7]

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    References:

    Cliffe et al (1993) (S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. J.Med.Chem. 36 1509. Fletcher et al (1993) WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur.J.Pharmacol. 237 283. Fletcher et al (1993) Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents. TiPS 14 441. Rodgers and Cole (1994) Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test. Eur.J.Pharmacol. 261 321.
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    Keywords: (S)-WAY 100135 Dihydrochloride, 5-HT Receptors, Potent, Selective 5-HT1A Antagonist, WAY100135 Dihydrochloride, Tocris Bioscience
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