|
Category:
|
7TM Receptors Acetylcholine (Muscarinic) ReceptorsAntagonists
|
|
Cat.No.
|
Product Name
|
|
0532 |
W-84 dibromide
|
|
|
|
Price and Availability
Click here for full price details of
W-84 dibromide
|
|
Chemical Name:
Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammoni
um]dibromide |
|
|
Biological Activity:
Stabilises cholinergic antagonist-receptor complexes by an
allosteric effect. Thus increases the protective effect of atropine against
organophosphate poisoning.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
|
|
|
References:
Mitchelson (1975) Antimuscarinic action of an alkane-bis ammonium
compound alone and in combination with (+)-bensetimide. Eur.J.Pharmacol. 33
237. Jepsen et al (1988) Allosteric stabilisation of [3H]-N-methylscopolamine
binding in guinea pig myocardium by an antidote against organophosphate
intoxication. Pharmacol.Toxicol. 63 163. Mohr et al
(1992) Equipotent allosteric effect of W84 on [3H]-NMS binding to cardiac
muscarinic receptors from guinea-pig, rat and pig. Pharmacol.Toxicol. 70
198.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: W-84 Dibromide, Acetylcholine (Muscarinic) Receptors, Antagonist-receptor Complex Stabiliser , W84 Dibromide, Tocris Bioscience
|
|
|
