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Category: Cellular Processes and ComponentsarrowSignal TransductionarrowCalcium SignallingarrowCalcium Binding Protein Modulators
Cat.No. Product Name
0369 W-7 hydrochloride  
Price and Availability

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W-7 hydrochloride
Chemical Name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

Biological Activity:

Calmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM).

Technical Data:

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M.Wt: 377.33
Formula: C16H21ClN2O2S.HCl 
Storage: Store at RT
Solubility: Soluble to 5 mM in Water and to 5 mM in Ethanol
CAS No: [61714-27-0]

Resources:

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    References:

    Tanaka and Hidaka (1980) Hydrophobic regions function in calmodulin-enzyme(s) interactions. J.Biol.Chem. 255 11078. Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.USA 78 4354. Itoh and Hidaka (1984) Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 96 1721. Asano et al (1989) Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W 7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 251 764.
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    Keywords: W-7 Hydrochloride, Signal Transduction, Calmodulin Antagonist. Inhibits Myosin Light Chain Kinase, W7 Hydrochloride, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    Mechanisms for Manipulating Intracellular Calcium Buffering
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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