W-13 Hydrochloride | Signal Transduction | Calmodulin Antagonist | W13 Hydrochloride

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Cat.No.	Product Name
0361	W-13 hydrochloride

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W-13 hydrochloride

Chemical Name: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride

Biological Activity:

Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC₅₀ of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.

Technical Data:

M.Wt:	349.27
Formula:	C₁₄H₁₇ClN₂O₂S.HCl
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Water and to 100 mM in DMSO
CAS No:	[88519-57-7]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods In Enzymol. 102 185. Stroble and Peterson (1992) Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pimozide and the calmodulin antagonist, W-13. J.Pharmacol.Exp.Ther. 263 186. Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21^cip1. J.Biol.Chem. 272 22145.

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Keywords: W-13 Hydrochloride, Signal Transduction, Calmodulin Antagonist, W13 Hydrochloride, Tocris Bioscience

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