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Category:
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Transporters Neurotransmitter Transporters5-HT Transporters
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Cat.No.
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Product Name
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2917 |
Venlafaxine hydrochloride
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| Alternative name(s): |
Wy-45030 |
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Price and Availability
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Venlafaxine hydrochloride
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Chemical Name:
1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexa
nol hydrochloride |
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Biological Activity:
Dual serotonin/noradrenaline reuptake inhibitor
that displays ~ 30-fold higher affinity for SERT than NET (Ki values
are 82 and 2480 nM respectively). Antidepressant; increases swimming and
climbing behaviour in the forced-swim test in rats.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Bymaster et al (2001)
Comparative affinity of duloxetine nd venlafaxine for serotonin and
norepinephrine transporters in vitro and in vivo, human serotonin
receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 25
871. Magalas et al (2005) The serotonin/noradrenaline reuptake
inhibitor venlafaxine attenuates acquistion, but not maintenance, of
intravenous self-administration of heroin in rats. Eur.J.Pharmacol. 528
103. Gould et al (2006) A comparison of the chronic treatment
effects of venlafaxine and other antidepressants on serotonin and
norepinephrine transporters. Biol.Psychiatry 59 408.
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Keywords: Venlafaxine Hydrochloride, Neurotransmitter Transporters, Dual Serotonin / Noradrenaline Reuptake Inhibitor, Wy-45030, Tocris Bioscience
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